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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22579

Title: Immunological evasion of immediate-early varicella zoster virus proteins
Authors: Meysman, Pieter
Fedorov, Dmitry
Van Tendeloo, Viggo
Ogunjimi, Benson
Laukens, Kris
Issue Date: 2016
Publisher: SPRINGER
Citation: IMMUNOGENETICS, 68(6-7), p. 483-486
Abstract: The varicella zoster virus (VZV) causes the childhood disease commonly known as chickenpox and can later in life reactivate as herpes zoster. The adaptive immune system is known to play an important role in suppressing VZV reactivation. A central aspect of this system is the presentation of VZV-derived peptides by the major histocompatibility complex (MHC) proteins. Here, we investigate if key VZV proteins have evolved their amino acid sequence to avoid presentation by MHC based on predictive models of MHC-peptide affinity. This study shows that the immediate-early proteins of all characterized VZV strains are profoundly depleted for high-affinity MHC-I-restricted epitopes. The same depletion can be found in its closest animal analog, the simian varicella virus. Further orthology analysis towards other herpes viruses suggests that the protein amino acid frequency is one of the primary drivers of targeted epitope depletion.
Notes: [Meysman, Pieter; Laukens, Kris] Univ Antwerp, Dept Math & Comp Sci, Antwerp, Belgium. [Meysman, Pieter; Laukens, Kris] Univ Antwerp, Univ Antwerp Hosp, Biomed Informat Res Ctr Antwerp Biomina, Edegem, Belgium. [Fedorov, Dmitry] Univ Bonn, Inst Cellular Neurosci, Bonn, Germany. [Van Tendeloo, Viggo; Ogunjimi, Benson] Univ Antwerp, Lab Expt Hematol LEH, Vaccine & Infect Dis Inst VAXINFECTIO, Antwerp, Belgium. [Ogunjimi, Benson] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis CHERMID, Vaccine & Infect Dis Inst VAXINFECTIO, Antwerp, Belgium. [Ogunjimi, Benson] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/22579
DOI: 10.1007/s00251-016-0911-4
ISI #: 000378819100009
ISSN: 0093-7711
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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