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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22563

Title: B cells and antibodies in progressive multiple sclerosis: Contribution to neurodegeneration and progression
Authors: Fraussen, Judith
de Bock, Laura
Somers, Veerle
Issue Date: 2016
Citation: AUTOIMMUNITY REVIEWS, 15(9), p. 896-899
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination, axonal degeneration and gliosis. The progressive form of MS is an important research topic as not much is known about its underlying mechanisms and no therapy is available. Although progressive MS is traditionally considered to be driven by neurodegeneration, compartmentalized CNS inflammation is currently accepted as one of the driving processes behind neurodegeneration and progression. In this review, the involvement of B cells and antibodies in progressive MS is discussed. The identification of meningeal ectopic B cell follicles in secondary progressive MS (SPMS) patients and the successful use of B cell-depleting therapy in primary progressive MS (PPMS) patients have underlined the importance of B cells in progressive MS. Proof is also available for the role of antibodies in neurodegeneration and progression in MS. Here, oligoclonal immunoglobulin M (IgM) production and autoreactive antibodies are described, with a focus on antibodies directed against sperm-associated antigen 16 (SPAG16). Further research into the role of B cells and autoantibodies in MS progression can lead to novel prognostic and theranostic opportunities.
Notes: [Somers, Veerle] Hasselt Univ, Biomed Res Inst, Martelarenlaan 42, B-3500 Diepenbeek, Belgium. [Somers, Veerle] Transnat Univ Limburg, Sch Life Sci, Martelarenlaan 42, B-3500 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/22563
DOI: 10.1016/j.autrev.2016.07.008
ISI #: 000382346700006
ISSN: 1568-9972
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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