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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2254

Title: The Arnold-Chiari type II malformation at midgestation
Authors: Beuls, Emile
Vanormelingen, Linda
van Aalst, J
Vandersteen, Marjan
Adriaensens, Peter
Cornips, E
Vles, H
Temel, Y
Gelan, Jan
Issue Date: 2003
Publisher: KARGER
Citation: PEDIATRIC NEUROSURGERY, 39(3). p. 149-158
Abstract: The Arnold-Chiari malformation type 11 (ACMII) is reported to be reversible after closure of a myelomeningocele at midgestation. To elucidate the developmental state of the ACMII malformation at the approximate time fetal surgery is performed, the ACMII of a 20-week human fetus was investigated in vitro using high-field magnetic resonance microscopy at 9.4 T and compared with the hindbrain of a neurologically intact fetus of the same gestational age. Up to 20 weeks of gestation, the developmental failures caused by the early embryonic herniation of the posterior fossa contents are the dominant feature of fetal ACMII, but after 20 weeks, the accelerated and disproportionate growth of the cerebellum dominates. As midgestational surgery stops the leakage of cerebrospinal fluid, the posterior fossa will expand in time to allow further normal growth of both the cerebellum and brain stem. Some early developmental anomalies already present in the primitive rhombencephalon due to early embryonic hindbrain herniation as well as some intra-axial anomalies are probably not reversible. Copyright (C) 2003 S. Karger AG, Basel.
Notes: Univ Limburg, Dept Anat, Diepenbeek, Belgium. Univ Limburg, Dept Mat Res, Diepenbeek, Belgium. Univ Maastricht, Dept Pediat Neurol, Maastricht, Netherlands. Univ Maastricht, Dept Neurosurg, Maastricht, Netherlands.Beuls, E, Univ Hosp Maastricht, Dept Neurosurg, P Debyelaan 25,Postbus 5800, NL-6202 AZ Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/2254
DOI: 10.1159/000071653
ISI #: 000184775000007
ISSN: 1016-2291
Category: A1
Type: Journal Contribution
Validation: ecoom, 2004
Appears in Collections: Research publications

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