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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22533

Title: Systematic Analysis of the Cytokine and Anhedonia Response to Peripheral Lipopolysaccharide Administration in Rats
Authors: Biesmans, Steven
Matthews, Liam J. R.
Bouwknecht, Jan A.
De Haes, Patrick
Hellings, Niels
Meert, Theo F.
Nuydens, Rony
Ver Donck, Luc
Issue Date: 2016
Citation: Biomed Research International, 2016 (Art N° 9085273)
Abstract: Inflammatory processes may cause depression in subsets of vulnerable individuals. Inflammation-associated behavioral changes are commonly modelled in rodents by administration of bacterial lipopolysaccharide (LPS). However, the time frame in which immune activation and depressive-like behavior occur is not very clear. In this study, we showed that systemic administration of LPS robustly increased circulating levels of corticosterone, leptin, pro- and anti-inflammatory cytokines, and chemokines. Serum concentrations of most analytes peaked within the first 6 h after LPS injection and returned to baseline values by 24 h. Chemokine levels, however, remained elevated for up to 96 h. Using an optimized sucrose preference test (SPT) we showed that sickness behavior was present from 2 to 24 h. LPS-induced anhedonia, as measured by decreased sucrose preference, lasted up to 96 h. To mimic the human situation, where depression develops after chronic inflammation, rats were preexposed to repeated LPS administration or subchronic restraint stress and subsequently challenged with LPS. While these procedures did not increase the duration of anhedonia, our results do indicate that inflammation may cause depressive symptoms such as anhedonia. Using our SPT protocol, more elaborate rodent models can be developed to study the mechanisms underlying inflammation-associated depression in humans.
Notes: [Biesmans, Steven; Hellings, Niels; Meert, Theo F.] Hasselt Univ, BIOMED, Agoralaan C Bldg, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Matthews, Liam J. R.; Bouwknecht, Jan A.; De Haes, Patrick; Meert, Theo F.; Nuydens, Rony; Donck, Luc Ver] Div Janssen Pharmaceut NV, Janssen Res & Dev, Neurosci, Turnhoutseweg 30, B-2340 Beerse, Belgium.
URI: http://hdl.handle.net/1942/22533
DOI: 10.1155/2016/9085273
ISI #: 000380704000001
ISSN: 2314-6133
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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