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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2246

Title: Baseline health-related quality-of-life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer
Authors: Efficace, F
Biganzoli, L
Piccart, M
Coens, C
VAN STEEN, Kristel
Cufer, T
Coleman, RE
Calvert, HA
Gamucci, T
Twelves, C
Fargeot, P
Bottomley, A
Issue Date: 2004
Citation: EUROPEAN JOURNAL OF CANCER, 40(7). p. 1021-1030
Abstract: The potential value of baseline health-related quality-of-life (HRQOL) and clinical factors in predicting prognosis was examined using data from an international randomised phase III trial which compared doxorubicin and paclitaxel with doxorubicin and cylophosphamide as first line chemotherapy in 275 women with metastatic breast cancer. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the related breast module (QLQ-BR23) were used to assess baseline HRQOL data. The Cox proportional-hazards regression model was used for both univariate and multivariate analyses of survival. In the univariate analyses, performance status (P < 0.001) and number of sites involved (P = 0.001) were the most important clinical prognostic factors. The HRQOL variables at baseline most strongly associated with longer survival were better appetite, physical and role functioning, as well as less fatigue (P < 0.001). The final multivariate model retained performance status (P < 0.001) and appetite loss (P = 0.005) as the variables best predicting survival. Substantial loss of appetite was the only independent HRQOL factor predicting poor survival and was strongly correlated (\r\ > 0.5) with fatigue, role and physical functioning. In addition to known clinical factors, appetite loss appears to be a significant prognostic factor for survival in women with metastatic breast cancer. However, the mechanism underlying this association remains to be precisely defined in future studies. (C) 2004 Elsevier Ltd. All rights reserved.
Notes: EORTC Data Ctr, Qual Life Unit, B-1200 Brussels, Belgium. Inst Jules Bordet, B-1000 Brussels, Belgium. Limburgs Univ Centrum, Ctr Stat, Diepenbeek, Belgium. Inst Oncol, Ljubljana, Slovenia. Weston Pk Hosp, Sheffield, S Yorkshire, England. Univ Newcastle Upon Tyne, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. Frosinone Hosp, Frosinone, Italy. Univ Glasgow, Glasgow, Lanark, Scotland. Ctr Georges Francois Leclerc, Dijon, France.Efficace, F, EORTC Data Ctr, Qual Life Unit, Ave E,Mounier 83, B-1200 Brussels, Belgium.fef@eortc.be
URI: http://hdl.handle.net/1942/2246
DOI: 10.1016/j.ejca.2004.01.014
ISI #: 000221467400021
ISSN: 0959-8049
Category: A1
Type: Journal Contribution
Validation: ecoom, 2005
Appears in Collections: Research publications

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