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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22043

Title: Visual detection of cortical breaks in hand joints: reliability and validity of high-resolution peripheral quantitative CT compared to microCT
Authors: Scharmga, A.
Peters, Martijn
van Tubergen, A.
Van den Bergh, Joop
de Jong, J.
Loeffen, D.
van Rietbergen, B.
Weijers, R.
Geusens, Piet
Issue Date: 2016
Publisher: BIOMED CENTRAL LTD
Citation: BMC MUSCULOSKELETAL DISORDERS, 17 (Art N° 271)
Abstract: Background: To study the reliability and validity of high-resolution peripheral quantitative CT (HR-pQCT) with microCT (mu CT) as gold standard in the visual detection of cortical breaks in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. Methods: Ten cadaveric fingers (10 MCP and 9 PIP joints) were imaged by HR-pQCT and mu CT and visually analyzed by two independent readers. Intra-and interreader reliability were evaluated for the presence (yes/no, kappa statistics) and the total number (intraclass correlation coefficient, ICC) of cortical breaks. Sensitivity, specificity, positive and negative predictive value (PPV respectively NPV) of HR-pQCT in detecting cortical breaks were calculated. Results: With HR-pQCT, mean 149 cortical breaks were identified and with mu CT mean 129 (p < 0.05). Intrareader reliability for the presence of a cortical break per quadrant was 0.52 (95 % CI 0.48-0.56) and 0.71 (95 % CI 0.67-0.75) for HR-pQCT and mu CT, respectively, and for the total number of cortical breaks 0.61 (95 % CI 0.49-0.70) and 0.75 (95 % CI 0.68-0.82). Interreader reliability for the presence of a cortical break per quadrant was 0.37 (95 % CI 0.33-0.41) and 0.45 (95 % CI 0.41-0.49) for HR-pQCT and mu CT, respectively, and for the number of cortical breaks 0.55 (95 % CI 0.43-0.65) and 0.54 (95 % CI 0.35-0.67). Sensitivity, specificity, PPV and NPV of HR-pQCT were 81.6, 64.0, 81.6, and 64 % respectively. Conclusion: Cortical breaks were commonly visualized in MCP and PIP joints with HR-pQCT and mu CT. Reliability of both HR-pQCT and mu CT was fair to moderate. HR-pQCT was highly sensitive to detect cortical breaks with mu CT as gold standard.
Notes: [Scharmga, A.; Peters, M.; van Tubergen, A.; van den Bergh, J.; de Jong, J.; Geusens, P.] Maastricht Univ, Med Ctr, Dept Med, Div Rheumatol, POB 5800NL, NL-6202 AZ Maastricht, Netherlands. [Scharmga, A.; Peters, M.; van den Bergh, J.; de Jong, J.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Scharmga, A.; Peters, M.; van Tubergen, A.; Geusens, P.] Maastricht Univ, CAPHRI Sch Publ Hlth & Primary Care, Maastricht, Netherlands. [van den Bergh, J.] Viecuri Med Ctr, Dept Internal Med, Venlo, Netherlands. [van den Bergh, J.; Geusens, P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Loeffen, D.; Weijers, R.] Maastricht Univ, Med Ctr, Dept Radiol, Maastricht, Netherlands. [van Rietbergen, B.] Eindhoven Univ Technol, Dept Biomed Engn, Eindhoven, Netherlands.
URI: http://hdl.handle.net/1942/22043
DOI: 10.1186/s12891-016-1148-y
ISI #: 000379711600001
ISSN: 1471-2474
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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