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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21966

Title: Detection of novel diagnostic antibodies in ankylosing spondylitis: An overview
Authors: Quaden, Dana
De Winter, Liesbeth
Somers, Veerle
Issue Date: 2016
Citation: AUTOIMMUNITY REVIEWS, 15 (8), p. 820-832
Abstract: Ankylosing spondylitis (AS) is a debilitating, chronic, rheumatic disease characterized by inflammation and new bone formation resulting in fusion of the spine and sacroiliac joints. Since early treatment is impeded by a delayed diagnosis, it is highly important to find new biomarkers that improve early diagnosis and may also contribute to a better assessment of disease activity, prognosis and therapy response in AS. Because of the absence of rheumatoid factor, AS was long assumed to have a seronegative character and antibodies are thus not considered a hallmark of the disease. However, emerging evidence suggests plasma cells and autoantibodies to be involved in the disease course. In this review, the role of B cells and antibodies in AS is discussed. Furthermore, an overview is provided of antibodies identified in AS up till now, and their diagnostic potential. Many of these antibody responses were based on small study populations and further validation is lacking. Moreover, most were identified by a hypothesis-driven approach and thus limited to antibodies against targets that are already known to be involved in AS pathogenesis. Hence, we propose an unbiased approach to identify novel diagnostic antibodies. The already successfully applied techniques cDNA phage display and serological antigen selection will be used to identify antibodies against both known and new antigen targets in AS plasma. These newly identified antibodies will enhance early diagnosis of AS and provide more insight into the underlying disease pathology, resulting in a more effective treatment strategy and eventually an improved disease outcome.
Notes: [Quaden, Dana H.F.*; De Winter, Liesbeth M.*; Somers, Veerle] Hasselt Univ, Biomed Res Inst, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Quaden, Dana H.F.*; De Winter, Liesbeth M.*; Somers, Veerle] Transnatl Univ Limburg, Sch Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. *contributed equally to this work. Correspondence: veerle.somers@uhasselt.be
URI: http://hdl.handle.net/1942/21966
DOI: 10.1016/j.autrev.2016.06.001
ISI #: 000380598300006
ISSN: 1568-9972
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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