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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21845

Title: Hypophosphatemic osteomalacia: an unusual clinical presentation of multiple myeloma
Authors: Reyskens, M.
Sleurs, K.
Verresen, L.
Janssen, M.
van den Bergh, Joop
Geusens, P.
Issue Date: 2015
Citation: OSTEOPOROSIS INTERNATIONAL, 26 (7), p. 2039-2042
Abstract: An unusual case of a 75-year-old man is presented who had multiple stress fractures due to adult onset hypophosphatemic osteomalacia, which was the result of Fanconi syndrome, with light chain cast proximal tubulopathy due to multiple myeloma. A 75-year-old man presented with diffuse pain and muscle weakness. He had multiple stress fractures, low serum phosphate, decreased renal tubular reabsorption of phosphate, and normal PTH and FGF23, indicating adult onset hypophosphatemic osteomalacia. Phosphate supplements with calcitriol resulted in clinical recovery and healing of stress fractures. Because of proteinuria, a renal biopsy was performed that revealed Fanconi syndrome with light chain cast proximal tubulopathy and light kappa chains were found in serum and urine. A bone biopsy confirmed the diagnosis of multiple myeloma, and treatment with chemotherapy resulted in cytological and clinical recovery.
Notes: [Reyskens, M.; Sleurs, K.; Verresen, L.] Univ Hasselt, Diepenbeek, Belgium. [Verresen, L.; Janssen, M.] ZOL, Genk, Belgium. [Janssen, M.] Limburg Oncol Ctr, Hasselt, Belgium. [van den Berg, J.] VieCuri Med Ctr, Dept Internal Med, NL-5900 BX Venlo, Netherlands. [van den Berg, J.] Maastricht Univ Med Ctr, Dept Internal Med, NUTRIM Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands. [van den Berg, J.; Geusens, P.] Hasselt Univ, Biomed Res Ctr, B-3590 Diepenbeek, Belgium. [Geusens, P.] Maastricht Univ Med Ctr, CAPHRI, Dept Internal Med, Subdiv Rheumatol, NL-6200 MD Maastricht, Netherlands. [Geusens, P.] Acad Hosp azM, Dept Med, Subdiv Rheumatol, NL-6202 AZ Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/21845
DOI: 10.1007/s00198-015-3090-5
ISI #: 000356954500021
ISSN: 0937-941X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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