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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21841

Title: Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes
Authors: Casas, L.
Sunyer, J.
Tischer, C.
Gehring, U.
Wickman, M.
Garcia-Esteban, R.
Lehmann, I.
Kull, I.
Reich, A.
Lau, S.
Wijga, A.
Anto, J.M.
Nawrot, T. S.
Heinrich, J.
Keil, T.
Torrent, M.
Issue Date: 2015
Citation: ALLERGY, 70 (7), p. 820-827
Abstract: BackgroundExposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma. ObjectiveTo describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts. MethodsWe included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals. ResultsHouse dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1=3.3g/g) and LISAplus (GM Der f1=2.1g/g) and lowest in BAMSE (GM Der p1=0.1g/g, Der f1=0.3g/g). Moderate and high HDM concentrations were significantly (P-values<0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes. ConclusionOur study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.
Notes: [Casas, L.; Nawrot, T. S.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Ctr Environm & Hlth, B-3000 Louvain, Belgium. [Casas, L.; Sunyer, J.; Garcia-Esteban, R.; Anto, J. M.] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Casas, L.; Sunyer, J.; Garcia-Esteban, R.; Anto, J. M.] CIBER Epidemiol Salud Publ CIBERESP, Barcelona, Spain. [Sunyer, J.; Garcia-Esteban, R.; Anto, J. M.] Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain. [Sunyer, J.; Anto, J. M.] Univ Pompeu Fabra, Barcelona, Spain. [Tischer, C.; Heinrich, J.] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany. [Gehring, U.] Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands. [Wickman, M.; Kull, I.] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden. [Wickman, M.; Kull, I.] Sachs Childrens Hosp, Stockholm, Sweden. Karolinska Inst, Inst Environm Med, Stockholm, Sweden. [Lehmann, I.] FZ Helmholtz Ctr Environm Res Leipzig, Dept Environm Immunol, Leipzig, Germany. [Reich, A.; Keil, T.] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany. [Lau, S.] Charite, Klin Padiat M Pneumol & Immunol S, D-13353 Berlin, Germany. [Wijga, A.] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands. [Nawrot, T. S.] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Heinrich, J.] German Ctr Lung Res DZL, Comprehens Pneumol Ctr Munich CPC M, Munich, Germany. [Keil, T.] Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany. [Torrent, M.] IB SALUT, Area Salud Menorca, Menorca, Spain.
URI: http://hdl.handle.net/1942/21841
DOI: 10.1111/all.12626
ISI #: 000356366600009
ISSN: 0105-4538
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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