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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21833

Title: Genetic variation in pattern recognition receptors: functional consequences and susceptibility to infectious disease
Authors: Jaeger, Martin
Stappers, Mark H. T.
Joosten, Leo A. B.
Gyssens, Inge C.
Netea, Mihai G.
Issue Date: 2015
Citation: FUTURE MICROBIOLOGY, 10 (6), p. 989-1008
Abstract: Cells of the innate immune system are equipped with surface and cytoplasmic receptors for microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns and as such are crucial for the activation of the immune system. Currently, five different classes of PRRs have been described: Toll-like receptors, C-type lectin receptors, nucleotide-binding oligomerization domain-like receptors, retinoic acid-inducible gene I-like receptors and absent in melanoma 2-like receptors. Following their discovery, many sequence variants in PRR genes have been uncovered and shown to be implicated in human infectious diseases. In this review, we will discuss the effect of genetic variation in PRRs and their signaling pathways on susceptibility to infectious diseases in humans.
Notes: [Jaeger, Martin; Stappers, Mark H. T.; Joosten, Leo A. B.; Gyssens, Inge C.; Netea, Mihai G.] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands. [Stappers, Mark H. T.; Gyssens, Inge C.] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands. [Stappers, Mark H. T.; Gyssens, Inge C.] Hasselt Univ, Fac Med, Res Grp Immunol & Biochem, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/21833
DOI: 10.2217/FMB.15.37
ISI #: 000356025100009
ISSN: 1746-0913
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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