Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21803

Title: Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury
Authors: Geurts, Nathalie
Vangansewinkel, Tim
Lemmens, Stefanie
Nelissen, Sofie
Geboes, Lies
Schwartz, Christian
Voehringer, David
Hendrix, Sven
Issue Date: 2016
Citation: JOURNAL OF LEUKOCYTE BIOLOGY, 99 (4), p. 579-582
Abstract: Basophils are the smallest population of granulocytes found in the circulation. They have crucial and non-redundant roles in allergic disorders, in protection from parasite infections, in autoimmunity, and in the regulation of type 2 immunity. They share phenotypic and functional properties with mast cells, which exert substantial protective effects after traumatic brain injury and spinal cord injury, although they are considered one of the most proinflammatory cell types in the body. In contrast, the in vivo functions of basophils in central nervous system trauma are still obscure and not well studied. In this study, we show that by comparing spinal cord injury in wild type vs. basophil-deficient Mcpt8Cre transgenic mice, the locomotor recovery is not affected in mice depleted in basophils. In addition, no substantial differences were observed in the lesion size and in the astrocytic and macrophage/microglia reaction between both mouse strains. Hence, despite the multiple properties shared with mast cells, these data show, for the first time, to our knowledge, that basophils are dispensable for the functional recovery process after hemisection injury to the spinal cord in mice.
Notes: [Geurts, Nathalie; Vangansewinkel, Tim; Lemmens, Stefanie; Nelissen, Sofie; Geboes, Lies; Hendrix, Sven] Hasselt Univ, Dept Morphol, Biomed Res Inst, Diepenbeek, Belgium. [Nelissen, Sofie] Hasselt Univ, Dept Cell Physiol, Biomed Res Inst, Diepenbeek, Belgium. [Schwartz, Christian; Voehringer, David] Univ Clin Erlangen, Dept Infect Biol, Inst Clin Microbiol Immunol & Hyg, Erlangen, Germany. [Schwartz, Christian] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany.
URI: http://hdl.handle.net/1942/21803
DOI: 10.1189/jlb.3AB0815-370R
ISI #: 000371891100009
ISSN: 0741-5400
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
published version701.6 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.