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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21802

Title: Cardiopulmonary fitness is related to disease severity in multiple sclerosis
Authors: Heine, Martin
Wens, Inez
Langeskov-Christensen, Martin
Verschuren, Olaf
Op 't Eijnde, Bert
Kwakkel, Gert
Dalgas, Ulrik
Issue Date: 2016
Publisher: SAGE PUBLICATIONS LTD
Citation: MULTIPLE SCLEROSIS JOURNAL, 22 (2), p. 231-238
Abstract: Background: In persons with MS (pwMS), a lower cardiopulmonary fitness has been associated with a higher risk for secondary disorders, decreased functional capacity, symptom worsening and reduced health-related quality of life. Objective: To investigate the association between disease severity and cardiopulmonary fitness. Methods: Data from cardiopulmonary exercise tests, previously conducted in three different countries, were pooled. The association between disease severity (Expanded Disability Status Scale (EDSS)) and cardiopulmonary fitness (peak oxygen uptake (VO(2)peak)) was adjusted for age, sex and the country of origin. Results: The combined sample comprised 116 ambulant pwMS having a mean ( SD) EDSS score of 2.7 +/- 1.3. There was a significant correlation (r = -0.418, p < .01) between VO(2)peak and EDSS. A multiple regression model (R-2 = 0.520, p < .01) was constructed to describe VO(2)peak (mL.kg(-1).min(-1)); VO(2)peak = 36.622 - 5.433 (Sex (1=men)) - 0.124 (Age) - 2.082 (EDSS) + 2.737 (Belgium) + 8.674 (Denmark). Conclusion: There was a significant association between disease severity and cardiopulmonary fitness. The close relation between cardiopulmonary fitness and chronic conditions associated with physical inactivity, suggest a progressive increase in risk of secondary health conditions in pwMS
Notes: [Heine, Martin] Univ Med Ctr Utrecht, Inst Neurosci, Brain Ctr Rudolf Magnus, Rembrandtkade 10, NL-3583 TM Utrecht, Netherlands. [Heine, Martin; Verschuren, Olaf] Univ Med Ctr Utrecht, Ctr Excellence Rehabil Med, Rembrandtkade 10, NL-3583 TM Utrecht, Netherlands. [Heine, Martin; Verschuren, Olaf] Rehabil Ctr De Hoogstr, Rembrandtkade 10, NL-3583 TM Utrecht, Netherlands. [Heine, Martin; Verschuren, Olaf] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Rembrandtkade 10, NL-3583 TM Utrecht, Netherlands. [Wens, Inez; Eijnde, Bert O.] Hasselt Univ, Fac Med & Life Sci, Rehabil Res Ctr REVAL, Biomed Res Inst, Hasselt, Belgium. [Langeskov-Christensen, Martin; Dalgas, Ulrik] Aarhus Univ, Dept Publ Hlth, Sect Sport Sci, Aarhus, Denmark. [Kwakkel, Gert] Vrije Univ Amsterdam, Med Ctr, MOVE Res Inst Amsterdam, Dept Rehabil Med, Amsterdam, Netherlands. [Kwakkel, Gert] Ctr Rehabil & Rheumatol READE, Dept Neurorehabil, Amsterdam, Netherlands.
URI: http://hdl.handle.net/1942/21802
DOI: 10.1177/1352458515581437
ISI #: 000369981500014
ISSN: 1352-4585
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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