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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21773

Title: High Intensity Aerobic and Resistance Exercise Can Improve Glucose Tolerance in Persons With Multiple Sclerosis: A Randomized Controlled Trial.
Authors: Wens, Inez
Dalgas, Ulrik
Vandenabeele, Frank
Verboven, Kenneth
Hansen, Dominique
Deckx, Nathalie
Cools, Nathalie
Op 't Eijnde, Bert
Issue Date: 2016
Status: In Press
Abstract: Introduction: The prevalence of impaired glucose tolerance (IGT) is higher in persons with multiple sclerosis (MS) compared to healthy controls, indicating metabolic deficits that may increase comorbidity. In other populations, IGT can, at least partly, be reversed by intense physical exercise, but this is never investigated before in MS. Aim: To investigate the effect of high intensity aerobic and resistance training on glucose tolerance and skeletal muscle GLUT4 content in MS. Methods: Thirty-four persons with MS (aged 45 T 3 years, EDSS 2.5 T 1.07) were randomized into three groups, including a (1) sedentary control group (SED, n = 11), (2) 12-week high intensity interval plus resistance training group (HITR, n = 12), or (3) 12-week high intensity continuous aerobic training plus resistance training group (HCTR, n = 11). Before and after 12 weeks, glucose tolerance and skeletal muscle GLUT4 content were determined by an oral glucose tolerance test and analysis of a m.vastus lateralis biopsy, respectively. Results: There were no significant changes for subjects of SED. From pre- to post-intervention, total area under the glucose curve (tAUC) decreased significantly in both HITR (j6.9 T 6.2%) and HCTR (j11.0 T 7.7%) (P G 0.05). Insulin tAUC decreased (j12.3 T 14.7%) within HCTR and muscle GLUT4 content increased (+6.6 T 4.5%) in HITR. Conclusion: Twelve weeks of high intensity aerobic exercise in combination with resistance training improved glucose tolerance in persons with MS.
Notes: Wens, I (reprint author), Hasselt Univ, Fac Med & Life Sci, REVAL Rehabil Res Ctr, BIOMED Biomed Res Inst, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/21773
DOI: 10.1097/PHM.0000000000000563
ISI #: 000395005100010
ISSN: 0894-9115
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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