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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21728

Title: Investigating unmetabolized polycyclic aromatic hydrocarbons in adolescents' urine as biomarkers of environmental exposure
Authors: De Craemer, Sam
Croes, Kim
van Larebeke, Nicolas
Sioen, Isabelle
Schoeters, Greet
Loots, Ilse
Nawrot, Tim
Nelen, Vera
Campo, Laura
Fustinoni, Silvia
Baeyens, Willy
Issue Date: 2016
Citation: CHEMOSPHERE, 155, p. 48-56
Abstract: Polycyclic aromatic hydrocarbons (PAHs) are of interest to human biomonitoring studies due to their carcinogenic potential. Traditionally metabolites of these compounds, like 1-hydroxypyrene, are monitored in urine, but recent methods allow the determination of the parent compounds in urine, which give additional information regarding sources and toxicity of PAHs. In order to assess the feasibility of incorporating these methods in a human biomonitoring study, the 16 USEPA parent PAHs were determined in 20 urine samples. These samples were obtained from 10 boys and 10 girls aged 14-16 years, participating in the third Flemish Environment and Health Study (Flanders, Belgium). Of these 16 parent PAHs, nine could be determined in more than 95% of the samples and three (including benzo(a)pyrene) in more than 50%. Several correlations were found between different PAHs, but not between pyrene and its metabolite 1-hydroxypyrene. Diagnostic PAH ratios in urine and air samples pointed towards combustion sources and are in line with the ratios in environmental samples. Benzo(a)pyrene, naphthalene and fluorene have the highest carcinogenic potential in our cohort, when using toxic equivalency factors. Some associations between PAH congeners and determinants of exposure were found, while fluorene and acenaphthylene were positively associated with thyroid hormone levels and benzo(a)pyrene showed a positive correlation with DNA damage by comet assay. These results confirm that parent PAHs in urine are useful as biomarkers of exposure in biomonitoring studies. (C) 2016 Elsevier Ltd. All rights reserved.
Notes: [De Craemer, Sam; Croes, Kim; van Larebeke, Nicolas; Baeyens, Willy] Vrije Univ Brussel, Dept Analyt Environm & Geochem AMGC, Pleinlaan 2, B-1050 Brussels, Belgium. [van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy & Nucl Med, Study Ctr Carcinogenesis & Primary Prevent Canc, B-9000 Ghent, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium. [Schoeters, Greet] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Mol, Belgium. [Loots, Ilse] Univ Antwerp, Fac Polit & Social Sci, B-2020 Antwerp, Belgium. [Nawrot, Tim] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim] Leuven Univ KU Leuven, Dept Publ Hlth & Primary Care Occupat & Environm, Leuven, Belgium. [Nelen, Vera] Prov Inst Hyg, Antwerp, Belgium. [Fustinoni, Silvia] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy. [Campo, Laura; Fustinoni, Silvia] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Prevent, Milan, Italy.
URI: http://hdl.handle.net/1942/21728
DOI: 10.1016/j.chemosphere.2016.04.017
ISI #: 000377736100006
ISSN: 0045-6535
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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