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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21708

Title: Overview of the management of relapsing-remitting multiple sclerosis and practical recommendations
Authors: Gallo, P.
Van Wijmeersch, Bart
Issue Date: 2015
Citation: EUROPEAN JOURNAL OF NEUROLOGY, 22 (S2), p. 14-21
Abstract: The initial phases of the clinical course of relapsing-remitting multiple sclerosis (MS) are characterized by a mainly inflammatory pathology which gives way to a largely neurodegenerative process as the disease evolves. As all currently available disease-modifying therapies aim to control inflammation, the window of opportunity for use is early in the disease course, specifically at the time of a clinically isolated syndrome suggestive of MS or in the early stages of relapsing-remitting MS. Approximately 30% of patients treated with first-line immunomodulators (interferon-beta or glatiramer acetate) show a suboptimal response during the first 1-2 years and require a switch to an alternative therapy. It is recommended not to wait too long to switch in order to prevent disease progression. Patients with a poor prognosis in particular may require a timely switch to a second-line agent. Regular monitoring of disease and therapy in patients with MS is essential. In the first year after diagnosis, clinical evaluations (neurological status, symptomatic assessment, patient well-being) should be performed at baseline, 3, 6 and 12 months, and then every 6 months thereafter. Brain magnetic resonance imaging (MRI) should be performed every 6 months in the first year of treatment, and at least once yearly thereafter. A spinal cord MRI should be performed once yearly in patients presenting spinal symptoms.
Notes: [Gallo, P.] Univ Hosp Padova, Dept Neurosci, Multiple Sclerosis Ctr Veneto Reg CeSMuV, I-35128 Padua, Italy. [Van Wijmeersch, B.] Univ Hasselt, Rehabil & MS Ctr, Overpelt & Biomed Inst, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/21708
DOI: 10.1111/ene.12799
ISI #: 000369952200003
ISSN: 1351-5101
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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