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|Title: ||Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts|
|Authors: ||Clemente, Diana B. P.|
Fernandez, Mariana F.
Janssen, Bram G.
Santa Marina, Loreto
Nawrot, Tim S.
|Issue Date: ||2016|
|Publisher: ||US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE|
|Citation: ||ENVIRONMENTAL HEALTH PERSPECTIVES, 124 (5), p. 659-665|
|Abstract: ||BACKGROUND: Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE: We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight. METHODS: We used data from two independent European cohorts: INMA (n=376; Spain) and ENVIRONAGE (n=550; Belgium). Relative placental mtDNA content was determined as the ratio of two mitochondrial genes (MT-ND1 and MTF3212/R3319) to two control genes (RPLP0 and ACTB). Effect estimates for individual cohorts and the pooled data set were calculated using multiple linear regression and mixed models. We also performed a mediation analysis. RESULTS: Pooled estimates indicated that a 10-mu g/m(3) increment in average NO2 exposure during pregnancy was associated with a 4.9% decrease in placental mtDNA content (95% CI: -9.3, -0.3%) and a 48-g decrease (95% CI: -87, -9 g) in birth weight. However, the association with birth weight was significant for INMA (-66g; 95% CI: -111, -23g) but not for ENVIRONAGE (-20 g; 95% CI: -101, 62 g). Placental mtDNA content was associated with significantly higher mean birth weight (pooled analysis, interquartile range increase: 140 g; 95% CI: 43, 237 g). Mediation analysis estimates, which were derived for the INMA cohort only, suggested that 10% (95% CI: 6.6, 13.0 g) of the association between prenatal NO2 and birth weight was mediated by changes in placental mtDNA content. CONCLUSION: Our results suggest that mtDNA content can be one of the potential mediators of the association between prenatal air pollution exposure and birth weight.|
|Notes: ||[Clemente, Diana B. P.; Janssen, Bram G.; Pieters, Nicky; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. [Clemente, Diana B. P.; Casas, Maribel; Bustamante, Mariona; Carsin, Anne-Elie; Pedersen, Marie; Vrijheid, Martine; Sunyer, Jordi] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Casas, Maribel; Bustamante, Mariona; Fernandez, Mariana F.; Iniguez, Carmen; Llop, Sabrina; Olea, Nicolas; Pedersen, Marie; Santa Marina, Loreto; Souto, Ana; Tardon, Adonina; Vrijheid, Martine; Sunyer, Jordi] Inst Hlth Carlos III, CIBERESP, Madrid, Spain. [Vilahur, Nadia] Karolinska Inst, Inst Environm Med IMM, S-10401 Stockholm, Sweden. [Begiristain, Haizea; Vrijheid, Martine; Sunyer, Jordi] Hlth Res Inst BIODONOSTIA, Gipuzkoa, Spain. [Bustamante, Mariona] Univ Pompeu Fabra, Barcelona, Spain. [Bustamante, Mariona; Santa Marina, Loreto] CRG, Barcelona, Spain. [Fernandez, Mariana F.; Olea, Nicolas] Univ Granada, Dept Radiol, Granada, Spain. [Fernandez, Mariana F.; Olea, Nicolas] Hosp Univ San Cecilio, Ibs GRANADA, Inst Invest Biosanitaria Granada, Granada, Spain. [Fierens, Frans; Vanpoucke, Charlotte] Belgian Interreg Environm Agcy, Brussels, Belgium. [Gyselaers, Wilfried] East Limburg Hosp, Dept Obstet, Genk, Belgium. [Iniguez, Carmen; Llop, Sabrina] Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia, Spain. [Iniguez, Carmen] Univ Valencia, Valencia, Spain. [Lefebvre, Wouter] Flemish Inst Technol Res VITO, Mol, Belgium. [Pedersen, Marie] INSERM Natl Inst Hlth & Med Res, U823, Team Environm Epidemiol Appl Reprod & Resp Hlth, Inst Albert Bonniot, Grenoble, France. [Souto, Ana; Tardon, Adonina] Univ Oviedo, Univ Inst Oncol, Mol Epidemiol Canc Unit, Oviedo, Spain. [Sunyer, Jordi] Hosp del Mar, Res Inst, IMIM, Barcelona, Spain. [Nawrot, Tim S.] Katholieke Univ Leuven, Unit Environm & Hlth, Dept Publ Hlth & Primary Care, Leuven, Belgium.|
|ISI #: ||000377077000023|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2017|
|Appears in Collections: ||Research publications|
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