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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21701

Title: Contingent non-invasive prenatal testing: an opportunity to improve non-genetic aspects of fetal aneuploidy screening
Authors: Gyselaers, Wilfried
Hulstaert, Frank
Neyt, Mattias
Issue Date: 2015
Citation: PRENATAL DIAGNOSIS, 35 (13), p. 1347-1352
Abstract: Background Several countries today struggle with suboptimal performances in many aspects of the fetal aneuploidy screening process and consider introducing non-invasive prenatal screening (NIPT) as a solution. In this study, costs and benefits of different scenarios for contingent NIPT screening in Belgium are evaluated with respect to partial redistribution of the national screening budget into quality improving measures for those screening activities that will be maintained when full NIPT screening is implemented. Methods Data from the Belgian National Institute for Health and Disability Insurance and the Study Centre for Perinatal Epidemiology were used in modeled calculations of medical and economic impact of NIPT after prior conventional screening (1) at thresholds 1: 300 and 1: 600, and (2) at current and improved screening sensitivity. Results Contingent NIPT screening under current screening conditions would maintain today's 7.9(0)/(000) live birth prevalence of Down syndrome (LBPD) at an 11% reduction of overall short-term costs. Lowering the screening threshold to 1:600 or increasing sensitivity by 10% would reduce LBPD to 7(0)/(000) at a maximum 3% increase of overall short-term costs. Conclusion Today, in Belgium and in many other countries, full NIPT screening is considered too expensive for immediate introduction into the national fetal aneuploidy screening program. Contingent NIPT screening is both clinically and economically beneficial. A temporary contingent NIPT protocol allows for reinvesting economic savings into optimization of those screening aspects, which are to be maintained in parallel to full NIPT screening. (C) 2015 John Wiley & Sons, Ltd.
Notes: [Gyselaers, Wilfried] Ziekenhuis Oost Limburg, Dept Obstet & Gynecol, Genk, Belgium. [Gyselaers, Wilfried] Hasselt Univ, Dept Physiol, Hasselt, Belgium. [Hulstaert, Frank; Neyt, Mattias] Belgian Hlth Care Knowledge Ctr KCE, Brussels, Belgium.
URI: http://hdl.handle.net/1942/21701
DOI: 10.1002/pd.4704
ISI #: 000368445100012
ISSN: 0197-3851
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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