Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21659

Title: Correlates of Peripheral Blood Mitochondrial DNA Content in a General Population
Authors: Knez, Judita
Winckelmans, Ellen
Plusquin, Michelle
Thijs, Lutgarde
Cauwenberghs, Nicholas
Gu, Yumei
Staessen, Jan A.
Nawrot, Tim S.
Kuznetsova, Tatiana
Issue Date: 2016
Citation: AMERICAN JOURNAL OF EPIDEMIOLOGY, 183 (2), p. 138-146
Abstract: Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis and function that might produce a decrease in mtDNA content within cells. This implies that mtDNA content might be a potential biomarker associated with oxidative stress and inflammation. However, data on correlates of mtDNA content in a general population are sparse. Our goal in the present study was to describe in a randomly recruited population sample the distribution and determinants of peripheral blood mtDNA content. From 2009 to 2013, we examined 689 persons (50.4% women; mean age = 54.4 years) randomly selected from a Flemish population (Flemish Study on Environment, Genes, and Health Outcomes). Relative mtDNA copy number as compared with nuclear DNA was measured by quantitative real-time polymerase chain reaction in peripheral blood. There was a curvilinear relationship between relative mtDNA copy number and age. mtDNA content slightly increased until the fifth decade of life and declined in older subjects (Page 2 = 0.0002). mtDNA content was significantly higher in women (P = 0.007) and increased with platelet count (P < 0.0001), whereas it was inversely associated with white blood cell count (P < 0.0001). We also observed lower mtDNA content in women using estroprogestogens (P = 0.044). This study demonstrated in a general population that peripheral blood mtDNA content is significantly associated with sex and age. Blood mtDNA content is also influenced by platelet and white blood cell counts and estroprogestogen intake. Further studies are required to clarify the impact of chronic inflammation and hormone therapy on mitochondrial function.
Notes: [Knez, Judita; Thijs, Lutgarde; Cauwenberghs, Nicholas; Gu, Yumei; Staessen, Jan A.; Kuznetsova, Tatiana] Univ Leuven, Hypertens & Cardiovasc Epidemiol Res Unit, Dept Cardiovasc Sci, Biomed Sci Grp, B-3000 Leuven, Belgium. [Winckelmans, Ellen; Plusquin, Michelle; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Staessen, Jan A.] Maastricht Univ, R&D Grp VitaK, NL-6200 MD Maastricht, Netherlands. [Nawrot, Tim S.] Univ Leuven, Biomed Sci Grp, Dept Publ Hlth & Primary Care, Leuven, Belgium.
URI: http://hdl.handle.net/1942/21659
DOI: 10.1093/aje/kwv175
ISI #: 000369995600008
ISSN: 0002-9262
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
published version312.81 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.