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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21630

Title: The epidemiology of fractures in Denmark in 2011
Authors: Driessen, J. H. M.
Hansen, L.
Eriksen, S. A.
van Onzenoort, H. A. W.
Henry, R. M. A.
Van den Bergh, Joop
Abrahamsen, Bo
Vestergaard, P.
de Vries, F.
Issue Date: 2016
Citation: OSTEOPOROSIS INTERNATIONAL, 27 (6), p. 2017-2025
Abstract: In the present study, we used national health care databases to estimate fracture incidence rates (IRs) and compared these IRs based on imputed data. We showed that imputation could lead to both over- and underestimation of IRs, and future research should therefore focus on how to improve those imputations. Osteoporosis is a major public health burden through associated (osteoporotic) fractures. In Denmark, the incidence rates (IRs) of hip fracture are widely available. However, there is limited data about other fracture sites. A recent report could only provide imputed IRs, although nationwide data is readily available in electronic healthcare databases. Therefore, our aim was to estimate fracture site-specific IRs for Denmark in 2011 and to compare those to the previously reported imputed data. Data from the Danish National Hospital Discharge Register was used to estimate age- and gender-specific IRs for any fracture as well as for different fracture sites in the Danish population aged 20 years and older in 2011. Hip fracture IRs were stratified to sub-sites, and IRs were determined for all hip fractures which were confirmed by surgery. The total number of incident fractures in 2011 was 80,760 (IR 191, 95 % confidence interval (CI) 190-192 (per 10,000 person-years)), of which 35,398 (43.8 %, IR 171, 95 % CI 169-173) occurred in men and 45,362 (56.2 %, IR 211, 95 % CI 209-213) in women. The majority of the fractures occurred in the population aged 50 years and older (n = 50,470, IR 249, 95 % CI 247-251). The numbers of any hip fracture were lower than the previously imputed estimates, whereas the number of forearm fractures was higher. We showed age- and gender-specific fracture rates for any fracture as well as for different fracture sites. The IRs of most fracture sites increased with age. Estimating the number of fractures for Denmark based on imputation of data from other countries led to both over- and underestimation. Future research should therefore focus on how to improve those imputations as not all countries have nationwide registry data.
Notes: [Driessen, J. H. M.; de Vries, F.] Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. [Driessen, J. H. M.; de Vries, F.] Care & Publ Hlth Res Inst CAPHRI, Maastricht, Netherlands. [Driessen, J. H. M.; van Onzenoort, H. A. W.; de Vries, F.] Maastricht Univ, Dept Clin Pharm & Toxicol, Med Ctr, NL-6200 MD Maastricht, Netherlands. [Hansen, L.] Aalborg Univ, Dept Business & Management, Danish Ctr Healthcare Improvements, Aalborg, Denmark. [Eriksen, S. A.; Abrahamsen, B.] Aalborg Univ, Dept Clin Med, Aalborg, Denmark. [van Onzenoort, H. A. W.] Radboud Univ Nijmegen, Dept Pharm, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Henry, R. M. A.] Maastricht Univ, Dept Med, Med Ctr, NL-6200 MD Maastricht, Netherlands. [Henry, R. M. A.] Maastricht Univ, Cardiovasc Res Inst Maastricht, Med Ctr, NL-6200 MD Maastricht, Netherlands. [van den Bergh, J.] Maastricht Univ, Dept Internal Med, Med Ctr, NL-6200 MD Maastricht, Netherlands. [van den Bergh, J.] Univ Hasselt, Biomed Res Inst, Hasselt, Belgium. [Abrahamsen, B.] Univ Southern Denmark, Odense Patient Data Explorat Network, Inst Clin Res, Odense, Denmark. [Abrahamsen, B.] Holbaek Cent Hosp, Dept Med, Holbaek, Denmark. [Vestergaard, P.] Aalborg Univ Hosp, Dept Endocrinol, Aalborg, Denmark. [de Vries, F.] Southampton Gen Hosp, MRC Epidemiol Lifecourse Unit, Southampton SO9 4XY, Hants, England.
URI: http://hdl.handle.net/1942/21630
DOI: 10.1007/s00198-016-3488-8
ISI #: 000376100700008
ISSN: 0937-941X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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