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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21628

Title: Detection of Lung Cancer through Metabolic Changes Measured in Blood Plasma
Authors: Louis, Evelyne
Adriaensens, Peter
Guedens, Wanda
Bigirumurame, Theophile
Baeten Kurt
Vanhove, Karolien
Vandeurzen, Kurt
Darquennes, Karen
Vansteenkiste, Johan
Dooms, Christophe
Shkedy, Ziv
Mesotten, Liesbet
Thomeer, Michiel
Issue Date: 2016
Citation: JOURNAL OF THORACIC ONCOLOGY, 11 (4), p. 516-523
Abstract: Introduction: Low-dose computed tomography, the currently used tool for lung cancer screening, is characterized by a high rate of false-positive results. Accumulating evidence has shown that cancer cell metabolism differs from that of normal cells. Therefore, this study aims to evaluate whether the metabolic phenotype of blood plasma allows detection of lung cancer. Methods: The proton nuclear magnetic resonance spectrum of plasma is divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used to train a classification model in discriminating between 233 patients with lung cancer and 226 controls. The validity of the model was examined by classifying an independent cohort of 98 patients with lung cancer and 89 controls. Results: The model makes it, possible to correctly classify 78% of patients with lung cancer and 92% of controls, with an area under the curve of 0.88. Important moreover is the fact that the model is convincing, which is demonstrated by validation in the independent cohort with a sensitivity of 71%, a specificity of 81%, and an area under the curve of 0.84. Patients with lung cancer have increased glucose and decreased lactate and phospholipid levels. The limited number of patients in the subgroups and their heterogeneous nature do not (yet) enable differentiation between histological subtypes and tumor stages. Conclusions: Metabolic phenotyping of plasma allows detection of lung cancer, even in an early stage. Increased glucose and decreased lactate levels are pointing to an increased gluconeogenesis and are in accordance with recently published findings. Furthermore, decreased phospholipid levels confirm the enhanced membrane synthesis. (C) 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
Notes: [Louis, Evelyne; Vanhove, Karolien; Mesotten, Liesbet; Thomeer, Michiel] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Adriaensens, Peter; Guedens, Wanda] Hasselt Univ, Inst Mat Res, Biomol Design Grp, Hasselt, Belgium. [Adriaensens, Peter] Hasselt Univ, Inst Mat Res, Appl & Analyt Chem, Hasselt, Belgium. [Bigirumurame, Theophile; Shkedy, Ziv] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Baeten, Kurt] Janssen Diagnost BVBA, Beerse, Belgium. [Vanhove, Karolien] Algemeen Ziekenhuis Vesalius, Dept Resp Med, Tongeren, Belgium. [Vandeurzen, Kurt] Mariaziekenhuis Noord Limburg, Dept Resp Med, Overpelt, Belgium. [Darquennes, Karen] Ziekenhuis Maas Kempen, Dept Resp Med, Maaseik, Belgium. [Vansteenkiste, Johan; Dooms, Christophe] Katholieke Univ Leuven, Univ Ziekenhuizen, Dept Resp Med, Leuven, Belgium. [Mesotten, Liesbet] Ziekenhuis Oost Limburg, Dept Nucl Med, Genk, Belgium. [Thomeer, Michiel] Ziekenhuis Oost Limburg, Dept Resp Med, Schiepse Bos 6, B-3600 Genk, Belgium.
URI: http://hdl.handle.net/1942/21628
DOI: 10.1016/j.jtho.2016.01.011
ISI #: 000373864500007
ISSN: 1556-0864
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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