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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21580

Title: The Minimal Important Difference in Physical Activity in Patients with COPD
Authors: Demeyer, Heleen
Burtin, Chris
Hornikx, Miek
Camillo, Carlos Augusto
Van Remoortel, Hans
Langer, Daniel
Janssens, Wim
Troosters, Thierry
Issue Date: 2016
Citation: PLOS ONE, 11 (4)
Abstract: Background Changes in physical activity (PA) are difficult to interpret because no framework of minimal important difference (MID) exists. We aimed to determine the minimal important difference (MID) in physical activity (PA) in patients with Chronic Obstructive Pulmonary Disease and to clinically validate this MID by evaluating its impact on time to first COPD-related hospitalization. Methods PA was objectively measured for one week in 74 patients before and after three months of rehabilitation (rehabilitation sample). In addition the intraclass correlation coefficient was measured in 30 patients (test-retest sample), by measuring PA for two consecutive weeks. Daily number of steps was chosen as outcome measurement. Different distribution and anchor based methods were chosen to calculate the MID. Time to first hospitalization due to an exacerbation was compared between patients exceeding the MID and those who did not. Results Calculation of the MID resulted in 599 (Standard Error of Measurement), 1029 (empirical rule effect size), 1072 (Cohen's effect size) and 1131 (0.5SD) steps.day(-1). An anchor based estimation could not be obtained because of the lack of a sufficiently related anchor. The time to the first hospital admission was significantly different between patients exceeding the MID and patients who did not, using the Standard Error of Measurement as cutoff. Conclusions The MID after pulmonary rehabilitation lies between 600 and 1100 steps.day(-1). The clinical importance of this change is supported by a reduced risk for hospital admission in those patients with more than 600 steps improvement.
Notes: [Demeyer, Heleen; Burtin, Chris; Hornikx, Miek; Camillo, Carlos Augusto; Van Remoortel, Hans; Langer, Daniel; Troosters, Thierry] KU Leuven Univ Leuven, Dept Rehabil Sci, B-3000 Leuven, Belgium. [Demeyer, Heleen; Camillo, Carlos Augusto; Van Remoortel, Hans; Langer, Daniel; Janssens, Wim; Troosters, Thierry] Univ Hosp Leuven, Dept Resp Dis, B-3000 Leuven, Belgium. [Demeyer, Heleen] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Burtin, Chris] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Rehabil Res Ctr, Diepenbeek, Belgium. [Hornikx, Miek] Univ Hosp Leuven, Dept Cardiovasc Dis, B-3000 Leuven, Belgium. [Van Remoortel, Hans] Red Cross Flanders, Ctr Evidence Based Practice, Mechelen, Belgium.
URI: http://hdl.handle.net/1942/21580
DOI: 10.1371/journal.pone.0154587
ISI #: 000375211700107
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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