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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21557

Title: Designing biomedical proteomics experiments: state-of-the-art and future perspectives
Authors: Maes, Evelyne
Kelchtermans, Pieter
Bittremieux, Wout
De Grave, Kurt
Degroeve, Sven
Hooyberghs, Jef
Mertens, Inge
Baggerman, Geert
Ramon, Jan
Laukens, Kris
Martens, Lennart
Valkenborg, Dirk
Issue Date: 2016
Publisher: TAYLOR & FRANCIS LTD
Citation: EXPERT REVIEW OF PROTEOMICS, 13 (5), p. 495-511
Abstract: With the current expanded technical capabilities to perform mass spectrometry-based biomedical proteomics experiments, an improved focus on the design of experiments is crucial. As it is clear that ignoring the importance of a good design leads to an unprecedented rate of false discoveries which would poison our results, more and more tools are developed to help researchers designing proteomic experiments. In this review, we apply statistical thinking to go through the entire proteomics workflow for biomarker discovery and validation and relate the considerations that should be made at the level of hypothesis building, technology selection, experimental design and the optimization of the experimental parameters.
Notes: [Maes, Evelyne; Hooyberghs, Jef; Mertens, Inge; Baggerman, Geert; Valkenborg, Dirk] Vlaamse Instelling Technol Onderzoek, Appl Bio & Mol Syst, Boeretang 200, B-2400 Mol, Belgium. [Maes, Evelyne; Kelchtermans, Pieter; Mertens, Inge; Baggerman, Geert; Valkenborg, Dirk] Univ Antwerp, CFP, B-2020 Antwerp, Belgium. [Kelchtermans, Pieter; Degroeve, Sven; Martens, Lennart] VIB, Ctr Med Biotechnol, Ghent, Belgium. [Kelchtermans, Pieter; Degroeve, Sven; Martens, Lennart] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium. [Kelchtermans, Pieter; Degroeve, Sven; Martens, Lennart] Univ Ghent, Bioinformat Inst Ghent, B-9000 Ghent, Belgium. [Bittremieux, Wout; Laukens, Kris] Univ Antwerp, Dept Math & Comp Sci, B-2020 Antwerp, Belgium. [Bittremieux, Wout; Laukens, Kris] Univ Antwerp, Univ Antwerp Hosp, Biomed Informat Res Ctr Antwerp Biomina, B-2020 Antwerp, Belgium. [De Grave, Kurt; Ramon, Jan] Katholieke Univ Leuven, Dept Comp Sci, Leuven, Belgium. [Ramon, Jan] INRIA, France, France. [Valkenborg, Dirk] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/21557
DOI: 10.1586/14789450.2016.1172967
ISI #: 000375848400006
ISSN: 1478-9450
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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