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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21556

Title: Interleukin-25 is detrimental for recovery after spinal cord injury in mice
Authors: Dooley, Dearbhaile
Lemmens, Evi
Ponsaerts, Peter
Hendrix, Sven
Issue Date: 2016
Abstract: Background: The cytokine, interleukin (IL)-25, is thought to be critically involved in inducing a type 2 immune response which may contribute to regeneration after central nervous system (CNS) trauma. We investigated whether applying recombinant IL-25, locally or systemically, in a mouse model of spinal cord injury (SCI) improves functional and histological recovery. Findings: Repeated systemic administration of IL-25 did not influence functional recovery following SCI. In contrast, a single local administration of IL-25 significantly worsened locomotor outcome, which was evident from a decreased Basso mouse scale (BMS) score compared with phosphate-buffered saline (PBS)-treated controls. This was accompanied by a significant increase in lesion size, demyelination, and T helper cell infiltration. Conclusions: These data show for the first time that IL-25 is either ineffective when applied systemically or detrimental to spinal cord recovery when applied locally. Our findings question the potential neuroprotective role of IL-25 following CNS trauma.
Notes: [Dooley, Dearbhaile; Lemmens, Evi; Hendrix, Sven] Hasselt Univ, Biomed Res Inst, Dept Morphol, Diepenbeek, Belgium. [Dooley, Dearbhaile; Ponsaerts, Peter] Univ Antwerp, Vaccine & Infect Dis Inst Vaxinfectio, Lab Expt Hematol, B-2020 Antwerp, Belgium.
URI: http://hdl.handle.net/1942/21556
DOI: 10.1186/s12974-016-0566-y
ISI #: 000375900000001
ISSN: 1742-2094
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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