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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21540

Title: Performing two different actions simultaneously: The critical role of interhemispheric interactions during the preparation of bimanual movement
Authors: Fujiyama, Hakuei
Van Soom, Jago
Rens, Guy
Cuypers, Koen
Heise, Kirstin-Friederike
Levin, Oron
Swinnen, Stephan P.
Issue Date: 2016
Citation: CORTEX, 77, p. 141-154
Abstract: Even though it has been suggested that the dorsolateral prefrontal cortex (DLPFC) and dorsal premotor cortex (PMd) are highly involved in the planning of bimanual movements, the exact nature (facilitatory or inhibitory) of their role is not well understood. Using a dual site transcranial magnetic stimulation (TMS) paradigm, we examined the functional influence from DLPFC and PMd to the contralateral primary cortex (M1) during the preparation of a complex bimanual coordination task in which inter-hand movement frequency was manipulated. Only the left PMd showed inter-hand frequency-specific modulations in the interaction with the contralateral M1. Left PMd-right M1 interaction became facilitatory during the preparation phase when the left hand had to move faster than the right hand, while inhibitory modulation was observed when the movement frequency arrangement was reversed. Interestingly, bilateral DLPFC showed a facilitatory interaction with the contralateral M1s during the preparation period only in difficult conditions, irrespective of the inter-hand frequency ratio, suggesting a less task-specific role in the organization of complex bimanual actions. Observed task-related modulations in DLPFC-M1 and left PMd-right M1 interactions during preparation were significantly correlated with up-coming performance, predicting successful bimanual movements. These observations highlight the distinct roles of DLPFC and left PMd in the preparation of bimanual movements that require a differential contribution of each limb. (C) 2016 Elsevier Ltd. All rights reserved.
Notes: [Fujiyama, Hakuei; Van Soom, Jago; Rens, Guy; Cuypers, Koen; Heise, Kirstin-Friederike; Levin, Oron; Swinnen, Stephan P.] Katholieke Univ Leuven, Res Ctr Movement Control & Neuroplast, Grp Biomed Sci, Motor Control Lab, Leuven, Belgium. [Swinnen, Stephan P.] Katholieke Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, Leuven, Belgium. [Cuypers, Koen] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Fujiyama, Hakuei] Murdoch Univ, Sch Psychol, Murdoch, WA 6150, Australia.
URI: http://hdl.handle.net/1942/21540
DOI: 10.1016/j.cortex.2016.02.007
ISI #: 000374081600011
ISSN: 0010-9452
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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