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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2153

Title: Microhardness changes in dentine after neonatal capsaicin application
Authors: Krage, TL
Stiefel, A
Stephan, BM
Zimmer, S
Raab, WHM
Issue Date: 2005
Abstract: Aim To determine if desensitization of the nociceptive innervation in the dental pulp has an effect on odontoblast function in the rat. Methodology Neonatal systemic application of capsaicin was used to selectively eliminate nociceptive innervation. 12 capsaicin-treated rats were intravitally perfused at 150 days of life with 4% formaldehyde and jaws were prepared for Vicker's microhardness (VMH) measurement. As a control, 12 rats were injected with vehicle on the 3rd day of life and intravital perfusion was carried out exactly as those used for the experimental group. Immunohistological labeling of CGRP was carried out in both groups to assure the efficiency of desensitization in the experimental group. The VMH was measured in the incisors of each animal for a quantitative analysis of dentine quality. Results Vicker's microhardness was significantly higher in the control rats compared with the capsaicin-treated rats (P < 0.001). Conclusions Neonatal systemic application of capsaicin produces changes in the quality of dentine in the rat over time and therefore it is suggestive that selective elimination of the nociceptive innervation in pulpal tissue may effect odontoblast function.
Notes: Univ Dusseldorf, Dept Operat & Prevent Dent & Endodont, D-40225 Dusseldorf, Germany. Univ Halle Wittenberg, Dept Operat Dent & Periodont, Halle Saale, Germany. Limburgs Univ Ctr, Dept Histol, Diepenbeek, Belgium.Krage, TL, Univ Dusseldorf, Dept Operat & Prevent Dent & Endodont, Bldg 18-73,Moorenstr 5, D-40225 Dusseldorf, Germany.krage@med.uni-duesseldorf.de
URI: http://hdl.handle.net/1942/2153
DOI: 10.1111/j.1365-2591.2005.01000.x
ISI #: 000230432500012
ISSN: 0143-2885
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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