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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21517

Title: Clinical benefit of atrio-ventricular delay optimization in patients with a dual-chamber pacemaker: a pilot study The CBRAVO trial (NCT01998256)
Authors: Cools, Thijs
Daerden, Tara
Herbots, Lieven
Geukens, Robert
Verwerft, Jan
Koopman, Pieter
Dilling-Boer, Dagmara
Hansen, Dominique
Vranckx, Pascal
Dendale, Paul
Issue Date: 2016
Citation: ACTA CARDIOLOGICA, 71 (3), p. 257-265
Abstract: Objective: Outcome data on exercise capacity following atrio-ventricular (AV) optimization of dual-chamber pacing are sparse. Pacemaker settings are often left at manufacturers’ nominal values upon implantation. We studied the short-term effect of AV optimization on exercise capacity in patients with a dual-chamber pacemaker. Methods and results: Twenty-eight patients (mean age 73 ± 14 y) with a dual-chamber pacemaker, were randomized towards either nominal AV settings (group 1) or echo-guided AV optimization using the iterative mitral inflow VTI (velocity time integral) method (group 2) at baseline. At 4 weeks, patients were crossed-over to AV optimization in group 1 and returned to nominal AV settings in group 2 for another period of 4 weeks. Oxygen uptake efficiency slope improved significantly after AV optimization (by 126.7 mL/logL ± 190.7 mL/logL; P = 0.003). Conclusions: AV optimization in dual-chamber pacing significantly improved functional capacity after 4 weeks. These data provide the background for further validation studies.
Notes: Cools, T (reprint author), Jessa Hosp, Stadsomvaart 11, B-3500 Hasselt, Belgium thijs.cools@gmail.com
URI: http://hdl.handle.net/1942/21517
DOI: 10.2143/AC.71.3.3152085
ISI #: 000378444700002
ISSN: 0001-5385
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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