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|Title: ||Clinical benefit of atrio-ventricular delay optimization in patients with a dual-chamber pacemaker: a pilot study The CBRAVO trial (NCT01998256)|
|Authors: ||Cools, Thijs|
|Issue Date: ||2016|
|Citation: ||ACTA CARDIOLOGICA, 71 (3), p. 257-265|
|Abstract: ||Objective: Outcome data on exercise capacity following atrio-ventricular (AV) optimization of dual-chamber pacing are sparse. Pacemaker settings are often left at manufacturers’ nominal values upon implantation. We studied the short-term effect of AV optimization on exercise capacity in patients with a dual-chamber pacemaker.
Methods and results: Twenty-eight patients (mean age 73 ± 14 y) with a dual-chamber pacemaker, were randomized towards either nominal AV settings (group 1) or echo-guided AV optimization using the iterative mitral inflow VTI (velocity time integral) method (group 2) at baseline. At 4 weeks, patients were crossed-over to AV optimization in group 1 and returned to nominal AV settings in group 2 for another period of 4 weeks. Oxygen uptake efficiency slope improved significantly after AV optimization (by 126.7 mL/logL ± 190.7 mL/logL; P = 0.003).
Conclusions: AV optimization in dual-chamber pacing significantly improved functional capacity after 4 weeks. These data provide the background for further validation studies.|
|Notes: ||Cools, T (reprint author), Jessa Hosp, Stadsomvaart 11, B-3500 Hasselt, Belgium
|ISI #: ||000378444700002|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2017|
|Appears in Collections: ||Research publications|
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