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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2150

Title: Immunohistochemical evidence for proteolipid protein and nestin expression in the late bell stage of developing rodent teeth
Authors: STRUYS, Tom
Krage, T
Raab, WHM
Issue Date: 2005
Citation: ARCHIVES OF ORAL BIOLOGY, 50(2). p. 171-174
Abstract: In this study, the expression of proteolipid protein (PLP) and nestin is studied in the late bell stage of developing rodent teeth in neonatal rats. By using immunohistochemistry, it was shown that odontoblasts, ameloblasts and the stratum intermedium are positive for PLP in regions of active matrix deposition. Reactivity for nestin could be detected in the odontoblasts, stratum intermedium and in some of the apical, processes of the ameloblasts. The fact that mutations in the PLP gene can cause disturbances in tooth form, number and eruption taken together with the presence of PLP reactivity in odontoblasts and ameloblasts of healthy animals, suggests a crucial role for PLP in developing teeth because of its structural supportive characteristics. These results also imply the possible use of PLP antibody as a new marker for, respectively, dentin and enamel-secreting odontoblasts and ameloblasts. PLP and nestin expression could point to a possible similarity in function between the oligodendrocyte and the odontoblast, both derived from the neural crest. To compare with the situation in human tissue, PLP and nestin expression were preliminarily tested on human dental pulp. The odontoblasts were positive for both PLP and nestin. (c) 2004 Elsevier Ltd. All rights reserved.
Notes: Univ Limburg, Sch Life Sci, Biomed Onderzoekinst & Transnatl, Diepenbeek, Belgium. Univ Dusseldorf, Dept Operat Prevent Dent & Endodont, D-4000 Dusseldorf, Germany.Struys, T, Univ Limburg, Sch Life Sci, Biomed Onderzoekinst & Transnatl, Diepenbeek, Belgium.tom.struys@tuc.ac.be
URI: http://hdl.handle.net/1942/2150
DOI: 10.1016/j.archoralbio.2004.11.007
ISI #: 000227568000013
ISSN: 0003-9969
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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