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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21405

Title: Analysis of gene expression data in early drug development
Authors: KASIM, Adetayo
Advisors: Shkedy, Ziv
Issue Date: 2010
Abstract: ... In this dissertation, we mainly focus on inferential statistics for, (1) gene signatures for bivariate expression for translation of disease related gene signature across tissues and for evaluation of tissue surrogacy; (2) modeling of dose-response microarray experiments to identify genes that can serve as biomarkers for a therapeutic compound, and (3) probe level analysis of microarray experiments to identify and filter genes with irrelevant variations. We present in the subsequent paragraphs an overview of the different chapters of the dissertation. ...
URI: http://hdl.handle.net/1942/21405
Category: T1
Type: Theses and Dissertations
Appears in Collections: PhD theses
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