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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21355

Title: Microglia in the embryonic brain and spinal cord during the development of neuronal networks
Authors: Swinnen, Nina
Advisors: Rigo, Jean-Michel
Legendre, P.
Brône, Bert
Issue Date: 2013
Abstract: ... In this thesis, we aimed at characterizing the invasion pattern and phenotype of microglia in the embryonic brain. We focused on the developing cortex and choroid plexus to study the microglial characteristics by means of the expression of different immunohistochemical markers (Mac-2, Ki-67) and patch-clamp recordings (K+ channels, ATP-induced currents). Additionally, we investigated the microglial involvement in the developing cortex and hippocampal area in a poly (I:C)-induced maternal immune activation model for neurodevelopmental disorders. To these ends, we used a mouse model in which eGFP is expressed under the promoter of the fractalkine receptor, rendering microglia (progenitors) green fluorescent. The inflammation model used (i.p. single dose of poly (I:C) (20mg/kg)) is a well established model to induce maternal immune activation (MIA) and results in well documented neurodevelopmental deficits and behavioral changes in the offspring. ...
URI: http://hdl.handle.net/1942/21355
Category: T1
Type: Theses and Dissertations
Appears in Collections: PhD theses
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