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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2135

Title: Newer drug treatments: Their effects on fracture prevention
Authors: GEUSENS, Piet
Reid, D
Issue Date: 2005
Publisher: BAILLIERE TINDALL
Citation: BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 19(6). p. 983-989
Abstract: Drug treatment of osteoporosis is based on the knowledge of mechanisms of bone turnover and the manipulation of the cellular components of bone turnover in terms of recruitment, activation and apoptosis of the cells involved. Based on their mechanisms of action, drugs used in the treatment of osteoporosis can be divided into those that inhibit bone turnover (bisphosphonates, SERMs, calcitonin), those that stimulate bone turnover (parathyroid hormone), and those with mixed effects (strontium ranelate). In this chapter we discuss the anti-fracture effects of some newer drugs together with innovative aspects of intake (monthly oral intake for ibandronate) or mechanisms of action (parathyroid hormone and strontium ranelate). Some new drugs that are being studied for their potential anti-fracture effects are listed.
Notes: Univ Hasselt, Inst Biomed Res, Diepenbeek, Belgium. Univ Hosp, Dept Rheumatol, NL-6202 AZ Maastricht, Netherlands. Univ Aberdeen, Med Sch Foresterhill, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland.Geusens, P, Univ Hasselt, Inst Biomed Res, Campus Diepenbeek, Diepenbeek, Belgium.piet.geusens@scarlet.be
URI: http://hdl.handle.net/1942/2135
DOI: 10.1016/j.berh.2005.07.003
ISI #: 000233858700009
ISSN: 1521-6942
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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