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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21267

Title: Improved Molecular Imprinting Based on Colloidal Particles Made from Miniemulsion: A Case Study on Testosterone and Its Structural Analogues
Authors: Kellens, Evelien
Bové, Hannelore
Conradi, Matthias
D'Olieslaeger, Lien
Wagner, Patrick
Landfester, Katharina
Junkers, Thomas
Ethirajan, Anitha
Issue Date: 2016
Publisher: AMER CHEMICAL SOC
Citation: MACROMOLECULES, 49 (7), p. 2559-2567
Abstract: Molecularly imprinted polymers (MIPs) in the micron and submicron scale based on the bifunctional cross-linker N,O-bismethacryloylethanolamine (NOBE) have been synthesized using bulk and miniemulsion polymerization, respectively. MIPs with distinct selectivity for the template testosterone were obtained. Colloidal MIP particles made using the miniemulsion technique have significant advantages compared to bulk MIP counterparts owing to their small size, homogeneity, and increased surface, as is demonstrated by optical batch rebinding studies using a non imprinted polymer (NIP) as a negative control. Affinity and selectivity studies were also performed with the miniemulsion colloidal MIPs. These MIPs display largely increased imprint factors (6.8 vs 2.2) when compared to their bulk MIP counterparts. Further, selectivity studies by using analogue steroids show that colloidal MIPs also display a higher selectivity. In summary, miniemulsion MIPs show much better performance with respect to molecular recognition in aqueous solution, while providing at the same time the possibility for a water-based MIP synthesis.
Notes: [Kellens, Evelien; Bove, Hannelore; Conradi, Matthias; D'Olieslaeger, Lien; Wagner, Patrick; Junkers, Thomas; Ethirajan, Anitha] Hasselt Univ, Inst Mat Res, Wetenschapspk 1 & Agoralaan D, B-3590 Diepenbeek, Belgium. [Landfester, Katharina] Max Planck Inst Polymer Res, Ackermannweg 10, D-55128 Mainz, Germany.
URI: http://hdl.handle.net/1942/21267
DOI: 10.1021/acs.macromol.6b00130
ISI #: 000374195600018
ISSN: 0024-9297
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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