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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2115

Title: Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch
Authors: Bosmans, F
Sun, YM
Zhu, RH
Xiong, YM
Wang, DC
Tytgat, J
Issue Date: 2005
Citation: PROTEIN AND PEPTIDE LETTERS, 12(4). p. 363-367
Abstract: In this study, the effect of the scorpion α-like toxin BmK M I was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.
Notes: Katholieke Univ Leuven, Toxicol Lab, B-3000 Louvain, Belgium. Limburgs Univ Ctr, Biomed, Ctr Milieukunde, B-3590 Diepenbeek, Belgium. Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China.Tytgat, J, Katholieke Univ Leuven, Toxicol Lab, E Van Evenstr 4, B-3000 Louvain, Belgium.Jan.Tytgat@pharm.kuleuven.ac.be
URI: http://hdl.handle.net/1942/2115
DOI: 10.2174/0929866053765635
ISI #: 000229162900011
ISSN: 0929-8665
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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