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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21145

Title: Ionic strength dependent vesicle adsorption and phase behavior of anionic phospholipids on a gold substrate
Authors: Pramanik, Sumit Kumar
Seneca, Senne
Ethirajan, Anitha
Neupane, Shova
Renner, Frank Uwe
Losada-Perez, Patricia
Issue Date: 2016
Citation: Biointerphases, 11 (1)
Abstract: The authors report on the effect of ionic strength on the formation of supported vesicle layers of anionic phospholipids 1,2-dimyristoyl-sn-glycero-3-phospho-rac-glycerol (DMPG) and dimyristoylphosphatidylserine (DMPS) onto gold. Using quartz crystal microbalance with dissipation monitoring the authors show that vesicleadsorption is mainly governed by NaCl concentration, reflecting the importance of electrostatic interactions in anionic lipids, as compared to zwitterionic 1,2-dimyristoyl-sn-glycero-3-phosphocholine. At low ionic strength, low or no adsorption is observed as a result of vesicle–vesicle electrostatic repulsion. At medium ionic strength, the negative charges of DMPG and DMPS are screened resulting in larger adsorption and a highly dissipative intact vesicle layer. In addition, DMPS exhibits a peculiar behavior at high ionic strength that depends on the temperature of the process.
Notes: Losada-Perez, P (reprint author), Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. patricia.losadaperez@uhasselt.be
URI: http://hdl.handle.net/1942/21145
DOI: 10.1116/1.4939596
ISI #: 000374982200028
ISSN: 1934-8630
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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