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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20873

Title: Cytomegalovirus seropositivity is associated with herpes zoster
Authors: Ogunjimi, Benson
Hens, N.
Pebody, R.
Jansens, H.
Seale, H.
Quinlivan, M.
Theeten, H.
Goossens, Herman
Breuer, Judy
Beutels, Philippe
Issue Date: 2015
Citation: Human Vaccines & Immunotherapeutics 11(6), p. 1394-1399
Abstract: Herpes zoster (HZ) is caused by VZV reactivation that is facilitated by a declined immunity against varicella-zoster virus (VZV), but also occurs in immunocompetent individuals. Cytomegalovirus (CMV) infection is associated with immunosenescence meaning that VZV-specific T-cells could be less responsive. This study aimed to determine whether CMV infection could be a risk factor for the development of HZ. CMV IgG serostatus was determined in stored serum samples from previously prospectively recruited ambulatory adult HZ patients in the UK (N D 223) in order to compare the results with those from UK population samples (N D 1545) by means of a logistic regression (controlling for age and gender). Furthermore, we compared the UK population CMV seroprevalence with those from population samples from other countries (from Belgium (N1 D 1741, N2 D 576), USA (N D 5572) and Australia (N D 2080)). Furthermore, CMV IgG titers could be compared between UK HZ patients and Belgium N2 population samples because the same experimental set-up for analysis was used. We found UK ambulatory HZ patients to have a higher CMV seroprevalence than UK population samples (OR 1.56 [1.11 2.19]). CMV IgG seropositivity was a significant risk factor for HZ in the UK (OR 3.06 [1.32 7.04]. Furthermore, high CMV IgG titers (exceeding the upper threshold) were less abundant in CMV-seropositive Belgian N2 population samples than in CMV-seropositive UK HZ patients (OR 0.51 [0.31 0.82]. We found CMVseroprevalence to increase faster with age in the UK than in other countries (P < 0.05). We conclude that CMV IgG seropositivity is associated with HZ. This finding could add to the growing list of risk factors for HZ.
Notes: Correspondence to: Benson Ogunjimi; Email: benson.ogunjimi@uantwerp.be
URI: http://hdl.handle.net/1942/20873
DOI: 10.1080/21645515.2015.1037999
ISI #: 000356426800026
ISSN: 2164-5515
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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