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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20856

Title: Mixed model approaches for joint modeling of different types of responses
Authors: Ivanova, Anna
Molenberghs, Geert
Verbeke, Geert
Issue Date: 2015
Citation: Journal of Biopharmaceutical Statistics, 26 (4), p. 601-618
Abstract: In many biomedical studies, one jointly collects longitudinal continuous, binary, and survival outcomes, possibly with some observations missing. Random-effects models, sometimes called shared-parameter models or frailty models, received a lot of attention. In such models, the corresponding variance components can be employed to capture the association between the various sequences. In some cases, random effects are considered common to various sequences, perhaps up to a scaling factor; in others, there are different but correlated random effects. Even though a variety of data types has been considered in the literature, less attention has been devoted to ordinal data. For univariate longitudinal or hierarchical data, the proportional odds mixed model (POMM) is an instance of the generalized linear mixed model (GLMM; Breslow and Clayton, 1993). Ordinal data are conveniently replaced by a parsimonious set of dummies, which in the longitudinal setting leads to a repeated set of dummies. When ordinal longitudinal data are part of a joint model, the complexity increases further. This is the setting considered in this paper. We formulate a random-effects based model that, in addition, allows for overdispersion. Using two case studies, it is shown that the combination of random effects to capture association with further correction for overdispersion can improve the model’s fit considerably and that the resulting models allow to answer research questions that could not be addressed otherwise. Parameters can be estimated in a fairly straightforward way, using the SAS procedure NLMIXED.
Notes: Ivanova, A (reprint author), Katholieke Univ Leuven, I BioStat, Kapucijnenvoer 35, B-3000 Leuven, Belgium. anna.ivanova@med.kuleuven.be
URI: http://hdl.handle.net/1942/20856
DOI: 10.1080/10543406.2015.1052487
ISI #: 000377095800001
ISSN: 1054-3406
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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