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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20838

Title: Comparison of diagnostic accuracy of (111)In-pentetreotide SPECT and (68)Ga-DOTATOC PET/CT: A lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours
Authors: Van Binnebeek, S.
Vanbilloen, B.
Baete, K.
Terwinghe, C.
Koole, M.
Mottaghy, F. M.
Clement, P. M.
Mortelmans, L.
Bogaerts, Kris
Haustermans, K.
Nackaerts, K.
Van Cutsem, E.
Verslype, C.
Verbruggen, A.
Deroose, C.
Issue Date: 2016
Citation: EUROPEAN RADIOLOGY, 26(3), p. 900-909
Abstract: Objectives To compare the diagnostic accuracy of 111Inpentetreotide-scintigraphy with 68Ga-DOTATOC-positron emission tomography (PET)/computed tomography (CT) in patients with metastatic-neuroendocrine tumour (NET) scheduled for peptide receptor radionuclide therapy (PRRT). Incremental lesions (ILs) were defined as lesions observed on only one modality. Methods Fifty-three metastatic-NET-patients underwent 111In-pentetreotide-scintigraphy (24 h post-injection; planar+ single-photon emission CT (SPECT) abdomen) and whole-body 68Ga-DOTATOC-PET/CT. SPECT and PET were compared in a lesion-by-lesion and organ-by-organ analysis, determining the total lesions and ILs for both modalities. Results Significantly more lesions were detected on 68GaDOTATOC-PET/CT versus 111In-pentetreotide-scintigraphy. More specifically, we observed 1,098 lesions on PET/CT (range: 1–105; median: 15) versus 660 on SPECT (range: 0–73, median: 9) (p<0.0001), with 439 PET-ILs (42/53 patients) and one SPECT-IL (1/53 patients). The sensitivity for PET/CT was 99.9 % (95 % CI, 99.3–100.0), for SPECT 60.0 % (95 % CI, 48.5–70.2). The organ-by-organ analysis showed that the PET-ILs were most frequently visualized in liver and skeleton. Conclusion Ga-DOTATOC-PET/CT is superior for the detection of NET-metastases compared to 111In-pentetreotide SPECT. Key Points • Somatostatin receptor PET is superior to SPECT in detecting NET metastases • PET is the scintigraphic method for accurate depiction of NET tumour burden • The sensitivity of PET is twofold higher than the sensitivity of SPECT
URI: http://hdl.handle.net/1942/20838
DOI: 10.1007/s00330-015-3882-1
ISI #: 000370158500035
ISSN: 0938-7994
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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