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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20773

Title: Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors
Authors: Morelli, Giovanni
Ravanidis, Stylianos
Aourz, Najat
Neve, Rachael L.
Smolders, Ilse
Harvey, Robert J.
Rigo, Jean-Michel
Nguyen, Laurent
Brône, Bert
Issue Date: 2016
Citation: CEREBRAL CORTEX, 27 (3), pag. 1863-1877
Abstract: The development of the cerebral cortex is a complex process that requires the generation, migration, and differentiation of neurons. Interfering with any of these steps can impair the establishment of connectivity and, hence, function of the adult brain. Neurotransmitter receptors have emerged as critical players to regulate these biological steps during brain maturation. Among them, α2 subunit-containing glycine receptors (GlyRs) regulate cortical neurogenesis and the present work demonstrates the long-term consequences of their genetic disruption on neuronal connectivity in the postnatal cerebral cortex. Our data indicate that somatosensory cortical neurons of Glra2 knockout mice (Glra2KO) have more dendritic branches with an overall increase in total spine number. These morphological defects correlate with a disruption of the excitation/inhibition balance, thereby increasing network excitability and enhancing susceptibility to epileptic seizures after pentylenetetrazol tail infusion. Taken together, our findings show that the loss of embryonic GlyRα2 ultimately impairs the formation of cortical circuits in the mature brain.
Notes: Rigo, JM; Brone, B (reprint author), Hasselt Univ, BIOMED Res Inst, B-3500 Hasselt, Belgium. jeanmichel.rigo@uhasselt.be; lnguyen@ulg.ac.be; bert.brone@uhasselt.be
URI: http://hdl.handle.net/1942/20773
DOI: 10.1093/cercor/bhw025
ISI #: 000397636600014
ISSN: 1047-3211
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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