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|Title: ||Anti-SPAG16 antibodies in primary progressive multiple sclerosis are associated with an elevated progression index|
|Authors: ||de Bock, Laura|
Villar, Luisa M.
Alvarez-Cermeno, Jose C.
Van Wijmeersch, Bart
van Pesch, Vincent
|Issue Date: ||2015|
|Citation: ||EUROPEAN JOURNAL OF NEUROLOGY 23(4), p. 722-728|
|Abstract: ||Background and purpose: Sperm-associated antigen 16 (SPAG16), a sperm protein which is upregulated in reactive astrocytes in multiple sclerosis (MS) lesions, has recently been identified as a novel autoantibody target in MS. The aim of this study was to investigate whether anti-SPAG16 antibody levels differ between
MS subtypes (relapsing remitting, RR; primary or secondary progressive, PP, SP) and whether antibody positivity is associated with clinical characteristics.
Methods: Plasma anti-SPAG16 antibody levels were determined by recombinant protein enzyme-linked immunosorbent assay (ELISA) in 374 MS patients (274 RRMS, 39 SPMS and 61 PPMS) and 106 healthy controls.
Results: Significantly elevated anti-SPAG16 antibodies were found in 22% of MS patients with 93% specificity. Anti-SPAG16 seropositivity was associated with an increased Expanded Disability Status Scale (EDSS) in overall MS. A higher proportion of PPMS patients showed anti-SPAG16 antibody reactivity (34%) compared to RRMS (19%) and SPMS (26%), and presented with higher anti-SPAG16 antibody levels. Seropositive PPMS patients had a significantly increased progression index compared to seronegative patients.
Conclusions: Anti-SPAG16 antibodies are associated with an increased EDSS in overall MS, indicating that they are linked to a worse MS disease outcome. Moreover, the presence of anti-SPAG16 antibodies may be a biomarker for a more severe disease in PPMS patients, as indicated by an increased progression index.|
|Notes: ||Correspondence: V. Somers, Hasselt University, Biomedical Research
Institute, Martelarenlaan 42, B-3500 Hasselt, Belgium (tel.: +32-
11269202; fax: +32-11269299; e-mail: firstname.lastname@example.org)|
|ISI #: ||000372972300013|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2017|
|Appears in Collections: ||Research publications|
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