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|Title: ||Postoperative Inflammatory Response in Crohn's Patients: A Comparative Study|
|Authors: ||de Buck Van Overstraeten, A.|
Van Hoef, S.
Van Assche, G.
|Issue Date: ||2015|
|Publisher: ||OXFORD UNIV PRESS|
|Citation: ||JOURNAL OF CROHNS & COLITIS, 9 (12), p. 1127-1131|
|Abstract: ||Background and Aims: Surgery for Crohn's disease [CD] can be complicated by an enhanced inflammatory response. This retrospective study aims to compare the inflammatory response measured by C-reactive protein [CRP] in patients operated for CD with patients undergoing similar surgery for colorectal cancer [CRC]. Methods: All CD patients undergoing an ileocaecal resection between February 2001 and December 2013 were retrieved from a prospectively maintained database. The same number of patients with a CRC of the ascending colon, undergoing a laparoscopic right hemicolectomy between March 2009 and June 2014, were retrieved from a CRC database. CRP level during the first 7 postoperative days was used as primary outcome. Results: Totals of 112 consecutive CD patients (male 40.2%; median age: 32.3 yrs; interquartile range [IQR]: 25.2-45.1) and 112 consecutive CRC patients [male 53.6%; median age 71.6 yrs; IQR: 64.7-77.5] were included. Postoperative CRP level in the CD group was on average 27% higher compared with the CRC group [p = 0.02]. The day-specific differences in CRP values were 21% (p = 0.021, 95% confidence interval [CI]: 3% 41%), 41% [p = 0.005, 95% CI: 11% - 79%], 49% [p = 0.007, 95% CI: 11% - 96%], and 49% [p = 0.006, 95% CI: 12% - 100%] higher for CD patients at Days 1, 4, 5, and 6 respectively. The difference in postoperative CRP level was partially due to differences in preoperative CRP level. Conclusion: CD patients develop a higher postoperative CRP level, probably reflecting an enhanced postoperative inflammatory response, which may be triggered by a higher preoperative inflammatory state.|
|Notes: ||[Van Overstraeten, A. de Buck; Van Hoef, S.; Wolthuis, A.; D'Hoore, A.] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Abdominal Surg, Leuven, Belgium. [Vermeire, S.; Ferrante, M.; Van Assche, G.] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Gastroenterol, Leuven, Belgium. [Fieuws, S.] Univ Hosp Leuven, B-3000 Leuven, Belgium. [Fieuws, S.] Univ Hasselt, I Biostat, B-3000 Leuven, Belgium.|
|ISI #: ||000366483000010|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2017|
|Appears in Collections: ||Research publications|
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