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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20619

Title: Do you have the nerves to regenerate? The importance of neural signalling in the regeneration process
Authors: Pirotte, Nicky
Leynen, Nathalie
Artois, Tom
Smeets, Karen
Issue Date: 2016
Citation: DEVELOPMENTAL BIOLOGY, 409 (1), p. 4-15
Abstract: The importance of nerve-derived signalling for correct regeneration has been the topic of research for more than a hundred years, but we are just beginning to identify the underlying molecular pathways of this process. Within the current review, we attempt to provide an extensive overview of the neural influences during early and late phases of both vertebrate and invertebrate regeneration. In general, denervation impairs limb regeneration, but the presence of nerves is not essential for the regeneration of aneurogenic extremities. This observation led to the "neurotrophic factor(s) hypothesis", which states that certain trophic factors produced by the nerves are necessary for proper regeneration. Possible neuron-derived factors which regulate regeneration as well as the denervation-affected processes are discussed. (C) 2015 Published by Elsevier Inc.
Notes: [Pirotte, Nicky; Leynen, Nathalie; Artois, Tom; Smeets, Karen] Hasselt Univ, Ctr Environm Sci, Zool Biodivers & Toxicol, BE-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/20619
DOI: 10.1016/j.ydbio.2015.09.025
ISI #: 000367638800003
ISSN: 0012-1606
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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