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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20615

Title: Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy
Authors: Thi Thu Hoang, Ha
Leuridan, Elke
Maertens, Kirsten
Dac Nguyen, Trung
Hens, Niel
Ha Vu, Ngoc
Cabore, Raissa Nadege
Thi Duong, Hong
Huygen, Kris
Van Damme, Pierre
Duc Dang, Anh
Issue Date: 2016
Citation: VACCINE, 34 (1), p. 151-159
Abstract: A pertussis vaccination during pregnancy has recently been adopted in several countries to indirectly protect young infants. This study assessed the effect of adding a pertussis component to the tetanus vaccination, in the pregnancy immunization program in Vietnam. A randomized controlled trial was performed. Pregnant women received either a Tdap (tetanus, diphtheria acellular pertussis) vaccine or a tetanus only vaccine between 19 and 35 weeks' gestational age. Immunoglobulin G (IgG) against tetanus (TT), diphtheria (DT), pertussis toxin (PT), filamentous hemaglutinin (FHA) and pertactin (Pm) were measured using commercial ELISA tests, at baseline, 1 month after maternal vaccination, at delivery, and in infants from cord blood and before and after the primary series (EPI: month 2-3-4) of a pertussis containing vaccine. Significantly higher geometric mean concentrations (GMC) were observed for all 3 measured pertussis antigens in the offspring of the Tdap group, up to 2 months of age. One month after completion of the primary infant vaccination schedule, anti-Pm GMC, but not anti-PT and anti-FHA GMCs, was significantly (p = 0.006) higher in the control group. Maternal antibodies induced by vaccination during pregnancy close the susceptibility gap for pertussis in young infants. Limited interference with the infant vaccine responses was observed. Whether this interference effect disappears with the administration of a fourth vaccine dose is further studied. (C) 2015 Elsevier Ltd. All rights reserved.
Notes: [Leuridan, Elke; Maertens, Kirsten; Van Damme, Pierre] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, B-2610 Antwerp, Belgium. [Ha Thi Thu Hoang; Trung Dac Nguyen; Hong Thi Duong; Anh Duc Dang] Natl Inst Hyg & Epidemiol, Hanoi 10000, Vietnam. [Cabore, Raissa Nadege; Huygen, Kris] Natl Reference Ctr Bordetella, Serv Immunol, Sci Inst Publ Hlth WIV ISP, B-1180 Brussels, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Hasselt, Belgium. [Hens, Niel] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, Vaccine & Infect Dis Inst, B-2610 Antwerp, Belgium. [Ngoc Ha Vu] Vietnam Natl Univ, Sch Med & Pharm, Hanoi, Vietnam.
URI: http://hdl.handle.net/1942/20615
DOI: 10.1016/j.vaccine.2015.10.098
ISI #: 000367489500021
ISSN: 0264-410X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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