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Title: Impact of High Intensity Exercise on Muscle Morphology in EAE Rats
Authors: Wens, Inez
Dalgas, U.
Verboven, Kenneth
Kosten, L.
Stevens, An
Hens, Niel
Op 't Eijnde, Bert
Issue Date: 2015
Citation: PHYSIOLOGICAL RESEARCH, 64 (6), p. 907-923
Abstract: The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak work during isokinetic muscle performance in EAE-animals. However, exercise was not able to prevent muscle fiber atrophy.
Notes: [Wens, I.; Verboven, K.; Kosten, L.; Stevens, A.; Eijnde, B. O.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Dalgas, U.] Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Aarhus, Denmark. [Hens, N.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, N.] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modelling Infect Dis, B-2020 Antwerp, Belgium.
URI: http://hdl.handle.net/1942/20614
ISI #: 000367547900013
ISSN: 0862-8408
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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