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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20576

Title: Long-term antibody persistence after vaccination with a 2-dose Havrix (TM) (inactivated hepatitis A vaccine): 20 years of observed data, and long-term model-based predictions
Authors: Theeten, Heidi
Van Herck, Koen
Van Der Meeren, Olivier
Crasta, Priya
Van Damme, Pierre
Hens, Niel
Issue Date: 2015
Citation: Vaccine, 33 (42), p. 5723-5727
Abstract: Antibody persistence in two cohorts of adults, who received inactivated hepatitis A (HAV) vaccine (1440El.U; Havrix (TM); GSK Vaccines) according to a 0-6 or 0-12 month schedule in 1992-1993, has been measured annually. After 20 years, >97% of the subjects in both studies were seropositive for anti-HAV antibodies. Geometric mean concentrations in the according-to-protocol cohorts were 312 mIU/ml in 34/36 subjects vaccinated initially at 0-6 months (NCT00289757) and 317 mIU/ml in 85/86 subjects vaccinated at 0-12 months (NCT00291876). Over the whole follow-up period, seven subjects (2 + 5, respectively) lost circulating anti-HAV antibodies but mounted a strong response after HAV booster administration (1440El.U). Mathematical modelling, which was applied to assess true persistence at Year 20 (accounting for drop-outs and missing data), and to predict longer-term persistence confirmed previous estimates that seropositive anti-HAV levels would persist in >= 95% vaccinees at Year 30 and >= 90% at Year 40. (C) 2015 Elsevier Ltd.
Notes: [Theeten, Heidi; Van Hercka, Koen; Van Damme, Pierre; Hens, Niel] Univ Antwerp, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium. [Van Hercka, Koen] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium. [Van Der Meeren, Olivier; Crasta, Priya] Belgium & Mumbai, GlaxoSmithKline Wavre, Bombay, Maharashtra, India. [Hens, Niel] Hasselt Univ, Interunivers Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/20576
DOI: 10.1016/j.vaccine.2015.07.008
ISI #: 000364268500035
ISSN: 0264-410X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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