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Title: Obstetric and perinatal outcome of 1655 ICSI and 3974 IVF singleton and 1102 ICSI and 2901 lVF twin births: a comparative analysis
Authors: Ombelet, Willem
Cadron, Isabelle
Gerris, Jan
De Sutter, Petra
Bosmans, Eugene
Martens, Geoffrey
Ruyssinck, Gunther
Defoort, Paul
Molenberghs, Geert
Gyselaers, Wilfried
Issue Date: 2005
Abstract: A total of 3974 IVF and 1655 ICSI singleton births and 2901 IVF and 1102 ICSI twin births were evaluated. Pregnancies after both fresh and frozen transfers were included. IVF and ICSI singleton pregnancies were very similar for most obstetric and perinatal variables. The only significant difference was a higher risk for prematurity (< 37 weeks of amenorrhoea) in IVF pregnancies compared with ICSI pregnancies (12.4 versus 9.2%, OR = 1.39, 95% CI = 1.15-1.70). For twin pregnancies, differences were not statistically different except for a higher incidence of stillbirths in the ICSI group (2.08 versus 1.03%, OR = 2.04, 95% CI = 1.14-3.64). Intrauterine growth retardation with or without pregnancy-induced hypertension was observed more often in the ICSI group. Regression analysis of the data with correction for parity and female age showed similar results for twins. For singletons, this analysis showed similar results with the exception of low birth weight babies (< 2500 g), which were also observed more often in IVF pregnancies (9.6 versus 7.9%, OR = 0.79, CI = 0.65-0.98, P = 0.03). This large case-comparative retrospective analysis showed that the obstetric outcome and perinatal health of IVF and ICSI pregnancies is comparable.
Notes: Flemish Soc Obstet & Gynecol, Sci Board, Brussels, Belgium. SPE, Studiecentrum Perinatale Epidemiol, Brussels, Belgium. Genk Inst Fertility Technol, Dept Obstet & Gynecol, Genk, Belgium. Limburgs Univ Ctr, Ctr Stat, Diepenbeek, Belgium.Ombelet, W, Flemish Soc Obstet & Gynecol, Sci Board, Brussels, Belgium.willem.ombelet@pandora.be
URI: http://hdl.handle.net/1942/2049
Link to publication: https://www.academia.edu/22377341/Obstetric_and_perinatal_outcome_of_1655_ICSI_and_3974_IVF_singleton_and_1102_ICSI_and_2901_IVF_twin_births_a_comparative_analysis
DOI: 10.1016/S1472-6483(10)61302-8
ISI #: 000230501500019
ISSN: 1472-6483
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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