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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2048

Title: Perinatal outcome of ICSI pregnancies compared with a matched group of natural conception pregnancies in Flanders (Belgium): a cohort study
Authors: Ombelet, Willem
Peeraer, Karen
De Sutter, Petra
Gerris, Jan
Bosmans, Eugene
Martens, Guy
Ruyssinck, Gunther
Defoort, Paul
Molenberghs, Geert
Gyselaers, Wilfried
Issue Date: 2005
Citation: REPRODUCTIVE BIOMEDICINE ONLINE, 11(2). p. 244-253
Abstract: A retrospective cohort study was conducted with an intracytoplasmic sperm injection (ICSI) group and a naturally conceived comparison group. A total of 1655 singleton and 1102 twin ICSI births were studied with regard to perinatal outcome. Control subjects (naturally conceived pregnancies) were selected from a regional registry and were matched for maternal age, parity, place of delivery, year of birth and fetal sex. The main outcome measures were duration of pregnancy, birth weight, Apgar score < 5 after 5 min, neonatal complications, perinatal death and congenital malformations. Twin births, when compared with singletons, carry a much higher risk of poor perinatal outcome. For both ICSI singletons and ICSI twins, no significant difference was found between ICSI and naturally conceived pregnancies for all investigated parameters. After excluding like-sex twin pairs, ICSI twin pregnancies were at increased risk for perinatal mortality (OR = 2.74, CI = 1.26-5.98), prematurity (OR = 1.38, CI = 1.10-1.75) and low birth weight (OR = 1.34, CI = 1.06-1.69) compared with spontaneously conceived different-sex twin pairs. In conclusion, the perinatal outcome of ICSI singleton and twin pregnancies was very similar to that of spontaneously conceived pregnancies in this large cohort study. After excluding like-sex twin pairs, ICSI twins were at increased risk for prematurity, low birth weight and higher perinatal mortality compared with the natural conception comparison group.
Notes: Flemish Soc Obstet & Gynaecol, Sci Board, Brussels, Belgium. SPE, Brussels, Belgium. Genk Inst Fertil Technol, Dept Obstet & Gynecol, Genk, Belgium. Limburgs Univ Ctr, Ctr Stat, Diepenbeek, Belgium.Ombelet, W, Flemish Soc Obstet & Gynaecol, Sci Board, Brussels, Belgium.willem.ombelet@pandora.be
URI: http://hdl.handle.net/1942/2048
DOI: 10.1016/S1472-6483(10)60965-0
ISI #: 000231049700021
ISSN: 1472-6483
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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