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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2043

Title: Design and analysis of drug combination experiments
Authors: STRAETEMANS, Roel
O'BRIEN, Timothy
WOUTERS, Luc
Van Dun, J
Janicot, M
BIJNENS, Luc
BURZYKOWSKI, Tomasz
AERTS, Marc
Issue Date: 2005
Publisher: AKADEMIE VERLAG GMBH
Citation: BIOMETRICAL JOURNAL, 47(3). p. 299-308
Abstract: In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interaction indices. In addition the model corrects for the bias due to plate-location effects. The analysis is performed with PROC NLMIXED and SAS-code is provided. The approach is illustrated using data coming from an oncology study in which the inhibition effect of a combination of two compounds is studied using 96-well plates and a fixed-ratio design.
Notes: Limburgs Univ Ctr, Ctr Stat, B-3590 Diepenbeek, Belgium. Loyola Univ, Chicago, IL 60611 USA. Barrier Therapeut, Geel, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Beerse, Belgium.Straetemans, R, Limburgs Univ Ctr, Ctr Stat, Univ Campus, B-3590 Diepenbeek, Belgium.Roel.Straetemans@luc.ac.be
URI: http://hdl.handle.net/1942/2043
DOI: 10.1002/bimj.200410124
ISI #: 000230361800009
ISSN: 0323-3847
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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