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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2041

Title: An equivalence test for comparing DNA sequences
Authors: Van Steen, Kristel
Raby, Benjamin A.
Molenberghs, Geert
Thijs, Herbert
De Wit, Mieke
Peeters, Monika
Issue Date: 2005
Citation: PHARMACEUTICAL STATISTICS, 4(3). p. 203-214
Abstract: The practice of sequence alignment is constantly oscillating between the risk of overlooking important structure and that of discovering any arbitrarily defined kind of structure anywhere. On the other hand, the use of a condensed consensus sequence may lead to a substantial loss in valuable information. While adopting a Mahalanobis-type index we allow for a certain degree of uncertainty in the measurements. This uncertainty may be caused by inaccurate measurements or ambiguity. In this paper, we test the similarity between DNA sequences within the framework of equivalence testing, accounting for both variances and covariances between frequencies of nucleotides. Statistical methods for testing equivalence were first developed in the context of pharmacokinetics and later extended to the field of clinical trials. Nowadays, (bio)equivalence tests seem to be less frequently used outside the drug testing field, including statistical genetics. Copyright (c) 2005 John Wiley & Sons, Ltd.
Notes: Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. LUC, Ctr Stat, Diepenbeek, Belgium. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA. Beth Israel Deaconess Med Ctr, Div Pulm & Crit Care Med, Boston, MA 02215 USA. Harvard Univ, Sch Med, Boston, MA 02115 USA. Tibotec Virco, Mechelen, Belgium.Van Steen, K, Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.kvanstee@hsph.harvard.edu
URI: http://hdl.handle.net/1942/2041
DOI: 10.1002/pst.182
ISI #: 000232295300006
ISSN: 1539-1604
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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