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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20243

Title: B Cells Are Multifunctional Players in Multiple Sclerosis Pathogenesis: insights from Therapeutic interventions
Authors: Claes, Nele
Fraussen, Judith
Stinissen, Piet
Hupperts, Raymond
Somers, Veerle
Issue Date: 2015
Citation: Frontiers in Immunology, 6, Art. N° 642
Abstract: Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS) characterized by autoimmune inflammation and neurodegeneration. Historically, damage to the CNS was thought to be mediated predominantly by activated pro-inflammatory T cells. B cell involvement in the pathogenesis of MS was solely attributed to autoantibody production. The first clues for the involvement of antibody-independent B cell functions in MS pathology came from positive results in clinical trials of the B cell-depleting treatment rituximab in patients with relapsing-remitting (RR) MS. The survival of antibody-secreting plasma cells and decrease in T cell numbers indicated the importance of other B cell functions in MS such as antigen presentation, costimulation, and cytokine production. Rituximab provided us with an example of how clinical trials can lead to new research opportunities concerning B cell biology. Moreover, analysis of the antibody-independent B cell functions in MS has gained interest since these trials. Limited information is present on the effects of current immunomodulatory therapies on B cell functions, although effects of both first-line (interferon, glatiramer acetate, dimethyl fumarate, and teriflunomide), second-line (fingolimod, natalizumab), and even third-line (monoclonal antibody therapies) treatments on B cell subtype distribution, expression of functional surface markers, and secretion of different cytokines by B cells have been studied to some extent. In this review, we summarize the effects of different MS-related treatments on B cell functions that have been described up to now in order to find new research opportunities and contribute to the understanding of the pathogenesis of MS.
Notes: Correspondence: Somers Veerle veerle.somers@uhasselt.be
URI: http://hdl.handle.net/1942/20243
DOI: 10.3389/fimmu.2015.00642
ISI #: 000367058600001
ISSN: 1664-3224
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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