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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20242

Title: Classification and clinical characterization of metabolically “healthy” obese children and adolescents
Authors: Bervoets, Liene
Massa, Guy
Issue Date: 2016
Citation: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 29 (5), p. 553-560
Abstract: Background: Some obese children do not show cardiometabolic complications such as prediabetes, dyslipidemia or insulin resistance. Objective: To classify obese children and adolescents as metabolically “healthy” obese (MHO) on the basis of three different definitions, and to compare cardiometabolic features with metabolically unhealthy obese (MUO) children and adolescents. Subjects: 156 obese children and adolescents aged between 10 and 18. Methods: Subjects were classified as MHO or MUO using three definitions based on the: (1) pediatric International Diabetes Federation (IDF) criteria; (2) homeostatic model assessment of insulin resistance (HOMA-IR); (3) combination of the previous two definitions. Cardiometabolic features were compared between MHO and MUO subjects. Results: 6 to 19% obese children and adolescents were classified as MHO, and showed a better insulin sensitivity, lower prevalence of prediabetes, lower triglycerides and lower triglyceride-to-HDL-C ratio compared to MUO. Conclusion: Less than 20% obese children and adolescents are identified as MHO and show a healthier cardiometabolic profile as compared to MUO. Implementation of the proposed classifications in future clinical research could contribute towards the standardization of the MHO definition and offer new insights into the manifestation of the pediatric MHO phenotype.
Notes: Massa, G (reprint author), Jessa Hosp, Dept Pediat, Stadsomvaart 11, B-3500 Hasselt, Belgium. guy.massa@jessazh.be
URI: http://hdl.handle.net/1942/20242
DOI: 10.1515/jpem-2015-0395
ISI #: 000375209800005
ISSN: 0334-018X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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