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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2011

Title: Application of functional PPV-derivatives prepared via the sulfinyl precursor route as transducers in impedimetric biosensors
Authors: VAN SEVEREN, Ineke
COOREMAN, Peter
THOELEN, Ronald
LUTSEN, Laurence
WAGNER, Patrick
VANDERZANDE, Dirk
CLEIJ, Thomas
Issue Date: 2006
Publisher: AMER CHEMICAL SOC
Citation: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 231
Abstract: Conjugated polymers exibit attractive properties for application in biosensors. Especially PPV-type polymers are promising transducer materials. However, sufficiently high purity and low defect levels, which are essential for sensor applications, are difficult to achieve. A promising precursor route, the so-called sulfinyl route, is capable of solving this problem. Four functionalized PPV-type(co)polymers have been obtained via this precursor route and theirinteraction with biomolecules has been investigated. In a prototype impedemetric biosensor, antibody-antigen binding on these polymer films has been readily observed. The sensor characteristics are dependent on the functional groups of the polymers. On the relatively apolar MDMO PPV antibodies can be physically adsorbed and binding with their antigens is possible (sensor sensitivity below 10pmol). On some solar PPV-derivatives no adsorption of IgGs takes place, whereas on others IgGs can be covalently bonded. Hence, incorporation of appropriate side chains renders PPV-type polymers suitable for application in biosensors.
Notes: Hasselt Univ, IMO, Inst Mat Res, B-3590 Diepenbeek, Belgium. IMEC, Div IMOMEC, B-3590 Diepenbeek, Belgium.ineke.vanseveren@uhasselt.be
URI: http://hdl.handle.net/1942/2011
ISI #: 000238125909866
ISSN: 0065-7727
Category: M
Type: Journal Contribution
Appears in Collections: Research publications

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